Project Grant R43DK125131

The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $389,852 Project Grant to Dignify Therapeutics, LLC to develop novel drug formulations for treating urinary incontinence (UI) and overactive bladder (OAB) symptoms in the elderly. The grant supports a research project to create new intravesical (bladder-instilled) drug therapies that can block pain-sensing neurons and provide long-term relief of UI and OAB for elderly patients who are unresponsive to current treatments. The...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $782,916 to Dignify Therapeutics, LLC to develop a therapy for fecal incontinence and fecal urgency. The key product being developed is a proprietary compound that can inhibit sensitized colorectal afferent terminals, which are believed to be a root cause of these disabling...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...

This Project Grant award, with the ID R01DK141106, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $730,883 grant will fund research by the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the molecular and cellular mechanisms underlying visceral pain and cross-organ sensitization between the bladder and colon. The key objectives are to:...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $862,002 to investigate mechanisms for enhancing the motor function of fecal continence muscles to improve fecal incontinence in patients. The key objectives are to: 1) characterize the fatigability of anal canal and puborectalis continence muscles across adult age groups and sexes;...

This $625,060 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to elucidate the roles of distinct spinal cord cell types in mediating interstitial cystitis (IC)/bladder pain syndrome (BPS). The research, conducted by The Washington University in St. Louis, will use chemogenetics and optogenetics approaches to determine the...

The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...

This federal Project Grant award of $726,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing in the spinal cord and brainstem, with the goal of advancing understanding and treatment of visceral pain conditions such as irritable bowel syndrome,...

This federal Project Grant award R01DK138907 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $690,451 grant will fund research conducted by the University of Pittsburgh to investigate the role of bladder fibroblasts, specifically suburothelial fibroblasts (SUFs), in regulating bladder mucosal function and afferent nerve signaling. The research aims to...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $410,000.00 to The University of Texas Southwestern Medical Center to study the effects of glucagon-like peptide 1 (GLP-1) receptor agonists and brain-derived GLP-1 on the activity of neuropeptide Y/agouti-related peptide (NPY/AGRP) neurons and their impact on metabolism. The research aims to define the...