Project Grant R43DK115277

The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) awarded a $145,636 project grant (CFDA 93.350) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to evaluate the relationship between thyroid hormone levels and brown adipose tissue activity, transcriptome, and cellular composition in adult humans. The study aims to better understand the interaction between the thyroid axis and brown adipose tissue in the process of thermogenesis and energy...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $107,250 to the University of Oklahoma Health Sciences Center for a research project titled "NR2F2 PIONEERS NEONATAL BEIGE ADIPOGENESIS TO PROTECT AGAINST LATER-LIFE OBESITY." The research aims to investigate how exposure to high omega-6 fatty acids during early development...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) supports the development and validation of a new mouse model for targeting mature brown adipocytes. The $240,750 award to Children's Hospital Medical Center in Cincinnati, Ohio will be used to generate, validate, and make widely available a CRISPR/Cas9-engineered mouse model that utilizes a defined UCP1 promoter to efficiently and safely target...

This Federal Project Grant award of $202,076 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) aims to develop quantitative ultrasound (QUS) imaging methods for non-invasive characterization of white adipose tissue (WAT) microstructure. The key objectives are to: 1) validate QUS parameters as a method to measure adipocyte size, number...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research provides $604,853 to Rockefeller University to conduct a systems-based investigation of the genetic determinants of brown adipose tissue (BAT) function in humans. The research aims to discover genetic variants that regulate BAT and link them to cardiometabolic disease traits, with the long-term goal...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $677,629 to Baylor College of Medicine to investigate the role of microRNA-30a (miR-30a) in regulating the immune response in white adipose tissue and its impact on insulin sensitivity in obesity. The research aims to: 1) define the cell-specific effects of miR-30a on white adipose...

This Project Grant award, with Federal Grant Award ID R01DK139610, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $570,268 award to the Albert Einstein College of Medicine will fund a 5-year research project to investigate the role of the CCNC protein in regulating white adipose tissue remodeling and its impact on obesity and type 2 diabetes. The project...

This $9.1 million project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of fast multichannel magnetothermal genetics for neural circuit modulation. The goal is to create a wireless, injectable, and fast-acting neuromodulation technology using magnetic fields to heat genetically-targeted nanoparticles and activate thermoreceptors with sub-second latency. This will allow precise synchronization of neural stimulation...

This Project Grant award from the National Science Foundation (NSF), under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), provides $275,000 to Mellicell Inc. to develop an industrial-scale technology for drug development using mature human fat cells. The broader impact of this SBIR Phase I project is to enable the discovery and development of next-generation therapeutics for obesity and associated medical conditions that can be treated through weight loss. The award will...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $700,000 Project Grant (R01DK141041) to The Regents of the University of California, San Francisco (UCSF) to conduct research on the relationship between adipose tissue thermogenesis and fibrosis in people living with HIV (PLWH). The project aims to examine how a reduction in CD81+ adipogenic precursor cells, which are linked to beige/brown fat biogenesis and fibrosis, may contribute to insulin resistance...