Project Grant R43DE034614
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $241,500.00 to support research focused on identifying diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis (Pg). The goal is to elucidate the mechanisms by which Pg, a late-stage colonizer linked to periodontitis and other systemic conditions, overcomes...
- This federal Project Grant award of $311,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will be used by the University of Washington to conduct research to characterize the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease. The research aims to increase understanding of how inflammation is triggered and maintained during the...
- This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project focused on investigating the biogenesis and localization of gingipains - critical virulence factors of the oral pathogen Porphyromonas gingivalis. The $358,823 grant, awarded to Loma Linda University, aims to expand the understanding of gingipains' hemagglutinating/adhesive properties and the...
- This $762,432 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant was awarded to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of the CD73 enzyme in controlling inflammation and bone loss associated with...
- This Project Grant award, totaling $645,009.00 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to investigate the role of osteocytes and the nucleotide-binding oligomerization domain containing 1 (NOD1) receptor in the mechanism of alveolar bone loss associated with periodontal disease. The research, to be conducted by Augusta University Research Institute, Inc. (doing...
- This $385,116 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research on senescent periodontal ligament cells as a potential therapeutic target for age-associated periodontitis. The award to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) aims to investigate the mechanisms by which aging increases periodontal disease bone loss,...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $226,500 to investigate how oral bacterial pathogens affect aging-associated immune responses and whether inhibition of the inflammatory marker CD38 can alleviate inflammatory bone loss and aging-associated immune responses induced by oral pathogens. The project, conducted by the Medical University of South Carolina, aims...
- This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis. The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization to...
The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a severe condition affecting over 11% of the global population. The project will leverage the research team's discovery of a series of novel class IIB microcins that demonstrate broad-spectrum antimicrobial activity against Gram-negative pathogens. The ultimate goal is to create an effective, targeted, safe, and orally administered treatment to reduce symptoms and prevent recurrence of periodontitis, while preserving the healthy oral microbiome.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $309.0k | 8/8/25 |