This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $466,500.00 to develop near-infrared chemiluminescent and fluorescent (NIR CFL) chitosan-based nanoparticles (CNPs) to improve detection of micrometastatic cancer and guide image-guided surgery. The research aims to address limitations of current imaging modalities by creating CNPs that can be activated by body...
This $620,592 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop first-in-class short-wave infrared (SWIR) fluorophores for enhanced visualization of buried nerves during head and neck cancer surgeries. The project, led by Oregon Health & Science University, seeks to synthesize novel oxazine-based small molecule fluorophores that can penetrate deep tissues...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,352,406.84 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Dartmouth College. The grant funds the development of a noninvasive ultrasound-based molecular imaging tool to identify micrometastases in the lymphatics for head and neck cancer. The project involves synthesizing perfluorocarbon nanodroplet contrast agents targeted to cancer cell surface receptors, which will be used...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,347 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Light Research Inc., a small business based in Tucson, Arizona. The grant supports the optimization and commercialization of a compact multimodal intraoral camera that integrates polarized white light imaging, autofluorescence imaging, optical coherence tomography, and near-infrared transillumination imaging modalities. This...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $550,296 to support the development of an innovative multimodal imaging-based diagnostic platform to assess the risk of precancerous oral lesions. The key products and services to be delivered include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,403,398 Project Grant under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for a project titled "Precision Imaging of the Spatial Regulators of the Hybrid Epithelial/Mesenchymal State in Head and Neck Cancer." The goal of this 3-year project is to utilize advanced imaging approaches...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), is focused on developing an intraoral camera system integrated with artificial intelligence (AI) software to improve the detection and monitoring of dental caries (tooth decay). The $294,632 award to Greenmark Biomedical Inc. aims to create a minimally viable product (MVP) of an intraoral camera that can capture...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $808,264 to The Medical University of South Carolina to conduct research aimed at elucidating the mechanisms underlying filopodia-mediated intracellular delivery of small interfering RNAs (siRNAs) via a peptide carrier, with the goal of developing a targeted molecular therapy for oral cancer. The key focus of...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Federal Grant Program "Oral Diseases and Disorders Research" (CFDA 93.121), awarded a $799,270 Project Grant to Keraceuticals, Inc. The grant supports the development of a novel class of anticancer drugs called 1,3-thioureas for the treatment of oral squamous cell carcinoma (OSCC), the most common form of oral cancer. The key objectives of this Phase I project are to: 1) formulate the lead compound CIDD99 for...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), awarded a $306,633 Project Grant to Ther-Ai LLC for the development of CRANIAMAP, a software suite that aims to enhance the auto-segmentation and landmarking of cone beam computed tomography (CBCT) scans. The project, which runs from April 1, 2025 to December 31, 2025, will focus on two key objectives: 1) Improving the accuracy of...