This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $423,500.00 to Nova Southeastern University, Inc. to develop a humanized mouse model of periodontitis. The goal is to investigate the potential pathogenic role of the protein Semaphorin 4D expressed by human osteoclasts in the progression of periodontal disease. This advanced mouse model will allow researchers to...
This Project Grant award of $226,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define how oral pathogens affect aging-associated immune responses and whether inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-associated immune responses induced by oral pathogens. The research will be conducted by the Medical University of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The $1,705,144 award to the University of Pittsburgh will fund research to 1) identify specific cell surface markers to isolate and characterize human PRX1-expressing periodontal stem cells, 2) develop a strategy to harness these stem cells for complete...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $645,009 to the Augusta University Research Institute, Inc. to investigate the role of osteocyte NOD1 signaling in bone loss associated with periodontal disease. The key objectives are to: 1) determine if osteocytes use the NOD1 receptor to recognize periodontal pathogens and induce the bone resorption...
This Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a bio-inspired scaffold called "PerioPatch" to regenerate Sharpey's fibers and periodontal tissues. The key objectives are to: 1) develop and optimize a tubular matrix to guide periodontal ligament (PDL) principal fiber formation, 2) rebuild the microenvironment for Sharpey's fiber...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program provides $456,500.00 to the University of Southern California (USC) to conduct research on periodontal tissue regeneration. The key focus is to investigate the use of a supramolecular nanomaterial called peptide amphiphile (PA) to enhance the regenerative effects of the bioactive peptide leucine-rich amelogenin peptide...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis. The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization to...
This Project Grant award of $248,627 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) supports research to understand the role of T cell responses to the oral pathogen Aggregatibacter actinomycetemcomitans in the immunopathology of periodontal disease. The research aims to: 1) assess systemic T cell responses to this pathogen in human periodontal disease, and 2) determine the role of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $873,546 to the University of Texas Health Science Center at Houston to develop an "oral micro-drug factory" using engineered Limosilactobacillus reuteri bacteria to secrete the anti-inflammatory cytokine interleukin-10 (IL-10) for treating periodontitis. The goal is to locally administer the...