Project Grant R43DE033312

Award Date 9/12/23
Completion Date 9/11/24
Dollars Obligated $330K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), funds research to define the role of human papillomavirus (HPV) integration structures in driving heterogeneity and treatment outcomes for HPV-positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). The total award amount is $1,743,816, with a project period from August 1, 2024 to April 30, 2029. The research aims to:...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to validate a novel prognostic biomarker for oropharynx cancer patients. The $638,903 award, effective March 12, 2025 through December 31, 2029, supports the following key products and services: Analytical validation of the "HPVhet score" biomarker to establish reliability across diverse patient...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,657,748 Project Grant (Grant No. R01DE034300) to Case Western Reserve University (CWRU) to conduct research on "Dual P300 and P53 Reactivation in HPV+ Head and Neck Cancer." This grant, awarded under the NIDCR's Oral Diseases and Disorders Research program (CFDA 93.121), aims to extensively determine the mechanisms of action of p53 and p300 reactivation in response to the lead compound OHM1 in...
This $118,763 federal Project Grant award was provided by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to the University of Arizona to support a research project led by Dr. Robert Jackson. The goal of the project is to assess and characterize the transformative versus productive infection cycles of human papillomavirus type 16 (HPV16) in different oral epithelial subtypes, with a focus on determining...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a $164,000 pilot study to evaluate the feasibility and acceptability of using mail-delivered sample collection kits to detect oral human papillomavirus (HPV) DNA infection among a racially/ethnically diverse cohort of sexual minority men living with HIV. The study, conducted by The Regents of the University of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $249,000 in funding to The Trustees of the University of Pennsylvania to conduct research aimed at understanding how human papillomavirus (HPV) disrupts the DNA damage response in HPV-positive head and neck squamous cell carcinoma (HNSCC). The goal is to identify vulnerabilities that can be targeted with combination...
This federal Project Grant award, totaling $1,641,683.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award will fund research by The Trustees of the University of Pennsylvania to explore the interactions between human papillomavirus (HPV) oncoprotein E6 levels, mitochondrial function, and therapy resistance in HPV-positive oropharyngeal squamous cell carcinomas. Key objectives...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $204,688 to The Johns Hopkins University to develop novel immunotherapies for HPV-associated head and neck cancers. The research focuses on three key products: 1) Salmonella-derived nanoparticles (SOMV-9RE7) to effectively stimulate the immune system, 2) Albumin-fused cytokines (ALB-FLT3L and ALB-IFNB) to expand...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $637,738 Project Grant under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) to Louisiana State University Health Sciences Center New Orleans. The grant, effective September 16, 2024 through June 30, 2029, will fund research to investigate the role of antiretroviral therapy (ART) in increasing susceptibility to oral human papillomavirus (HPV) infection among people living with HIV and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $515,812 to support a prospective observational cohort study to investigate the progression of HPV-related oropharynx cancer (HPV-OPC) in people living with and without HIV. The study aims to: 1) examine how HPV-OPC progression differs between these two groups; 2) characterize the impact of HIV on oral HPV16...

This $329,737 Project Grant awarded on September 12, 2023 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is supporting the development of a rapid, easy-to-use diagnostic platform for the point-of-care detection of high-risk HPV in saliva. The grantee, Innotech Precision Medicine, Inc., is working to create an innovative electrochemical biosensor that combines CRISPR-Cas12 technology with their proprietary gold-leaf electrodes to enable accurate, low-cost screening and monitoring of HPV infection, which is linked to most oropharyngeal squamous cell carcinoma cases. The project aims to develop a prototype multiplex assay capable of detecting HPV-16, HPV-18, and an optimal reference gene from saliva samples, addressing the need for improved early detection and management of HPV-related diseases.

Generated 7/16/24, 6:17 AM