Development of a high throughput assay for rapid screening of congenital cytomegalovirus infection using dried blood spots
Ended Project Grant Awarded Last action
- Award ID
- R43DC019890
- Recipient
-
Microgen LLC UEI C6KMJUPNY6R3
- Awarding agency
-
National Institute on Deafness and Other Communincation Disorders
National Institutes of Health, Department of Health and Human Services
- Obligated
- $583,226
Award facts
- Assistance listing
- 93.173 Research Related to Deafness and Communication Disorders
- Completion date
- Place of performance
- La Marque, TX 77568, USA
Award details come from USAspending.gov.
Description
- Abstract
- Sensorineural hearing loss (snhl), a condition where the inner ear cannot convert sound into nerve impulses to the brain, is the most common congenital disease. The leading cause of non-genetic snhl is congenital cytomegalovirus (ccmv) infection, and the economic burden of snhl and its detrimental effect on language development in the US is estimated at nearly $4 billion annually. Studies show that prompt antiviral therapy can improve language development in children identified with hearing loss. However, the benefits of early antiviral treatment are highly dependent on rapid diagnosis. If there are no saliva or urine samples available, diagnosis of ccmv infection in children is only possible by examining dried blood spots (dbss) that are routinely collected at birth. However, current DNA extraction methods exhibit lower sensitivity to detect CMV in dbss when compared to saliva and urine. Microgen's one-step® platform, which integrates sample lysis and target amplification, is an innovative, low-cost, and user-friendly technology that can address this challenge. The goal of this project is to develop an inexpensive ($10 each) and rapid (15-25 min from sample to result) test for diagnosis of ccmv using dbss, allowing immediate counseling and treatment. Development of microgen's one-step® CMV DBS test will provide a new tool for diagnosis, especially in asymptomatic patients with delayed hearing loss.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $291,613 | |
| Original award | $291,613 |
Quick answers
Who received award R43DC019890?
R43DC019890 was awarded to Microgen LLC by National Institute on Deafness and Other Communincation Disorders (National Institutes of Health) on June 10, 2022.
How much is award R43DC019890 worth?
$583,226 has been obligated on R43DC019890.
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