Project Grant R43DC017634

This $999,998 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of Renerva LLC's Peripheral Nerve Matrix (PNM) technology. PNM is a tissue-based hydrogel derived from porcine nerve that aims to improve functional outcomes for patients with challenging peripheral nerve gap injuries. The Phase I project will optimize the PNM...

Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide...

This $631,703 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) aims to investigate the use of muscle progenitor (stem) cells for treating vocal fold paralysis. The research project, conducted by The Washington University, will test the effectiveness of implanting these cells into the laryngeal muscles of canine models to improve nerve recovery...

The University of Akron will conduct collaborative research on glial scar morphology to develop tunable biomimetic platforms for spinal cord injury repair under a $306,999 National Science Foundation project grant awarded June 1, 2021 through the Engineering program (CFDA 47.041). The three-year award will support research exploring glial scar tissue formation after spinal cord damage and applying those insights to create customizable synthetic platforms that mimic the natural extracellular...

This Project Grant awarded by the National Science Foundation (CFDA 47.041 - Engineering) to Cleveland State University (CSU) provides $500,000 in funding from January 1, 2025 to December 31, 2027 to develop bioprinted tissue scaffolds with Schwann cell density gradients and electrical conductivity for peripheral nerve regeneration. The goal is to understand how Schwann cell density gradients and electrical properties within the scaffolds can enhance the regeneration of injured peripheral...

The Department of the Army Medical Command awarded a $1.5 million Project Grant to the University of Miami to support research on the "Safety and Efficacy of Autologous Human Schwann Cell (AHSC) Augmentation in Severe Peripheral Nerve Injury (PNI)." The grant period runs from September 30, 2022 to September 29, 2026. The research aims to investigate using a patient's own Schwann cells, which support nerve growth, to treat severe injuries to peripheral nerves. This work aligns with...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $296,151 to Insoma Bio, Inc. to investigate the use of their proprietary Fractomer biomaterial to improve outcomes after peripheral nerve repair. The project aims to demonstrate that Fractomer, an injectable polypeptide scaffold, can provide the necessary mechanical support and...

This Project Grant award, valued at $470,293.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award aims to identify the electrophysiological characteristics of spinal motor neurons during the recovery stages following a spinal cord injury (SCI) in mouse models. The study will employ soft, stretchable hydrogel microelectrodes to...

This $483,492 Project Grant awarded by the National Science Foundation's Engineering program to the University of Maryland, College Park, aims to develop biomaterial tools for investigating how extracellular matrix (ECM) ligands influence the function of macrophage immune cells. The 5-year project will leverage polyethylene glycol-based biomaterials with known peptide-derived ECM ligands to quantify the impact of ECM ligand-integrin receptor interactions on macrophage activation. The research...

This $961,052 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund a two-year study by Microcures Inc. to develop a nanoparticle-encapsulated siRNA therapy targeting the Fidgetin-like 2 (FL2) protein to promote tissue repair and functional recovery after spinal cord injury. The project will assess the efficacy of this treatment approach through...