Synthetic biology for splice modulating polyketides
Ended Project Grant Awarded Last action
- Award ID
- R43CA287469
- Recipient
-
Varigen Biosciences Corp UEI XLMBJ8BVWPZ3
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $297,088
Award facts
- Assistance listing
- 93.395 Cancer Treatment Research
- Completion date
- Place of performance
- Wisconsin, USA
Award details come from USAspending.gov.
Description
- Abstract
- Natural product-derived RNA splice modulators are being developed for the treatment of acute myeloid leukemia as well as other cancers. As natural products with complex molecular architectures, analogue synthesis, evaluation, and production scale up have proven challenging. Here we utilize the tools of synthetic biology as a platform to synthesize complex polyketide splice modulators. The most established set of splice modulators share a common mode of action targeting the SF3B multi-protein component within the U2- snrnp of the spliceosome. They also share a common motif comprised of two functional moieties united through a central diene. Combining the molecular diversity provided by medicinal chemistry with the flexibility and the ability to scale metabolite production using synthetic biology, we will produce 17S-FD-895, a highly potent, in vivo active lead for AML. This will overcome the chemical production bottleneck that is preventing this life saving compound from reaching clinical trials. From this medicinal synthetic biology approach, we will identify a promising production candidate that has the pre-clinical credentials to be further developed as a novel anticancer therapeutic.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $297,088 |
Quick answers
Who received award R43CA287469?
R43CA287469 was awarded to Varigen Biosciences Corp by National Cancer Institute (National Institutes of Health) on July 1, 2024.
How much is award R43CA287469 worth?
$297,088 has been obligated on R43CA287469.
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