Project Grant R43AT012434
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 provides funding to Clue Genetics Inc. for the development of a fungi-focused metabologenomics platform for natural product discovery. The key products and services to be delivered under this 1-year Phase I SBIR project include: Annotating biosynthetic gene clusters (BGCs) from 200 genomes selected from a diverse set of bioactive fungi to uncover new drugs,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $308,925 to Chemia Biosciences, Inc. to develop computational technologies for discovering novel fungal natural products with potential antimicrobial and therapeutic applications. The primary goal is to create software that can predict the molecular structures of natural products encoded in fungal genomes, leveraging high-throughput...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $495,117 to the University of Wisconsin System for a project titled "Accessing the Hidden Biosynthetic Capabilities of Fungi". The project aims to advance natural product discovery from filamentous fungi by: (1) elucidating the products of fungal gene clusters encoding unusual enzymes and chemistries, (2) examining how...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, has awarded a $300,156 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Intact Genomics Inc., a minority-owned small business. The funding will support research to identify new antifungal compounds with novel mechanisms of action from filamentous fungi. The key objectives are to demonstrate the use of Aspergillus nidulans as a...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This $955,781 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) funds research at Clark University to study the diversity, evolution, and origin of secondary metabolism in commensal microscopic filamentous fungi. The key research activities include: Reconstructing the evolutionary relationships among Basidiobolus fungal species. Exploring how secondary metabolite genes vary across Basidiobolus species and testing whether some genes were acquired...
- The National Center for Complementary and Integrative Health (NCCIH), part of the U.S. Department of Health and Human Services, awarded a $306,872 Project Grant under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to Evoquant LLC. The funding supports the development of the "BioPredictor" platform, an innovative artificial intelligence and multi-omics system designed to enhance natural product drug discovery and target selection. The project...
- This federal Project Grant award of $436,001 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to create a novel spatial transcriptomics platform that increases accessibility and efficiency. The key products and services to be delivered include: Developing a spatial transcriptomics platform using a simple filter array format that increases sequencing depth per spatial barcode, enabling more data per...
- This federal Project Grant award for $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of new tools for high-throughput characterization of extracellular RNA, DNA, and vesicles in bodily fluids. The primary objectives are to: 1) develop methods to reliably control for technical variability, RNA degradation, and complexity in cell-free RNA (cfRNA) analysis, including...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
This federal Project Grant award from the National Institutes of Health's National Center for Complementary and Integrative Health (CFDA 93.213 - Research and Training in Complementary and Integrative Health) provides $295,306.00 to Varigen Biosciences Corp to develop a universal fungal transposase system for increasing natural product and protein titers. The research aims to address limitations in heterologous strain performance for fungal natural products and enzymes, which represent large and growing global markets. The project will build a fungal transposase toolkit for heterologous overexpression and overexpress natural product biosynthetic gene clusters using the transposase-enabled multiple integration approach. This technology is expected to revolutionize the production of high-titer fungal strains, similar to how it has transformed mammalian cell line engineering. The award has an ultimate completion date of August 31, 2024.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $295.3k | 9/5/23 |