This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of Collamedix Inc.'s "ALLOBRACE" - a collagen-based sheath designed to enhance the integration and performance of allograft soft tissue transplants used in anterior cruciate ligament (ACL) reconstruction procedures. The $300,000 award will fund research to refine the ALLOBRACE design and evaluate its ability to guide cellular infiltration, tissue production, and bone growth when used in conjunction with allograft ACL transplants in a porcine animal model. The goal is to improve the biological integration and biomechanical properties of allograft ACL transplants, which can have higher failure rates compared to autograft procedures but avoid donor site morbidity. The results from this Phase I study will inform future larger-scale in vivo evaluations of ALLOBRACE's load-sharing capacity and performance compared to other ACL reconstruction devices.