A novel role for reelin therapeutics in rheumatoid arthritis
Ended Project Grant Awarded Last action
- Award ID
- R43AR081762
- Recipient
-
Reelin Therapeutics, Inc. UEI KTUYMKC7J4P5
- Awarding agency
-
National Insititue of Arthritis and Musculoskeletal and Skin Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $600,000
Award facts
- Assistance listing
- 93.846 Arthritis, Musculoskeletal and Skin Diseases Research
- Completion date
- Place of performance
- San Diego, CA 92130, USA
Award details come from USAspending.gov.
Description
- Abstract
- Chronic inflammatory pathology of cartilage and bone represents a major source of damage to the synovial joints observed in rheumatoid arthritis (RA). Although the precise etiology of these diseases is often unknown, excessive leukocyte extravasation is a substantial contributor to the tissue damage/inflammation and our recent data show a prominent role of the plasma protein, reelin in this process. Furthermore, we have now shown that IT is possible, using anti-reelin monoclonal antibodies, to deplete the plasma of reelin, which results in a significant reduction of a wide range of vascular adhesion molecule expression. Thus, in contrast to the current methods of depleting individual adhesion molecules or immune receptors, our anti-reelin approach systematically downregulates all major inflammation-driven adhesion proteins on the vascular endothelium. The purpose of this proposal is to demonstrate the role of reelin in RA by 1) identifying high affinity reelin antibodies and 2) validating the therapeutic potential of mitigating chronic inflammatory milieu with an anti-reelin antibody in an RA mouse model.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $300,000 | |
| Original award | $300,000 |
Quick answers
Who received award R43AR081762?
R43AR081762 was awarded to Reelin Therapeutics, Inc. by National Insititue of Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) on September 1, 2022.
How much is award R43AR081762 worth?
$600,000 has been obligated on R43AR081762.
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