Project Grant R43AI188960
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $427,000.00 to the New York Blood Center, Inc. to establish a continuous in vitro culture system for the Babesia microti parasite in human red blood cells. The goal is to create a robust platform to enable future experimental investigation and characterization of the human red blood cell receptor-B. microti ligand...
- This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the structural, morphological, rheological, and functional changes that occur in red blood cells (RBCs) infected by the Babesia parasite, the causative agent of babesiosis. The overarching goal is to identify the key Babesia proteins, including proteases, that interact with and alter the host...
- This $431,143 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 (Allergy and Infectious Diseases Research) supports the development of in vitro culture methods for propagating the parasite Babesia microti. B. microti causes the infectious disease babesiosis, which has become an increasing public health concern in the Northeastern United States. The funded research project aims to (1) propagate B. microti within tick cell lines, (2)...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the development of a novel universal rapid test for HIV diagnosis. IGE Immunodiagnostics & Therapeutics, LLC, a minority-owned small business, will receive $294,948 to adapt their existing HIV ELISA test into a 5th generation antigen/antibody combination rapid test format. The goal is to create a simple, rapid,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $238,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, San Diego (UCSD) to develop a novel electrochemical lateral flow assay (ELFA) for point-of-need tuberculosis (TB) detection. The objective is to create a highly sensitive and specific ELFA test that can accurately diagnose active TB, even in challenging populations like those with HIV...
- This federal Project Grant award of $250,573 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate how host genetic factors influence tick-transmitted Babesia microti infection. The key objectives are to identify polymorphic host genes and pathways that contribute to variability in disease progression and severity during acute B. microti infection, using the...
- This $300,000 Project Grant, awarded by the USDA's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (CFDA 10.310) program, will support the development of a sensitive, high-throughput multiplex diagnostic assay to simultaneously detect six major tick-borne pathogens, including Anaplasma, Borrelia, Ehrlichia, Rickettsia, Babesia, and Theileria. This assay will leverage barcoded magnetic bead technology to rapidly identify the causative agents of...
- The National Science Foundation (NSF) awarded a $550,000 Project Grant under the NSF Technology, Innovation, and Partnerships (TIP) program to the University of California, Los Angeles (UCLA) to develop a rapid, multiplexed diagnostic tool for serological testing of tick-borne diseases (TBDs). This 2-year project seeks to improve blood-based detection of TBDs, including Lyme disease, Babesia, Anaplasma, and relapsing fever, through an innovative point-of-care (POC) serological assay. The goal is...
- The federal Project Grant award of $850,711 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at the Albert Einstein College of Medicine to develop novel biomarkers for the detection of tuberculosis (TB). The goal is to identify highly sensitive and specific non-sputum-based point-of-care tests (POCTs) for active TB diagnosis, particularly in resource-limited settings and people living...
- The Project Grant award of $299,954 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports the development of a novel multivalent peptide vaccine against malaria. The project aims to (I) optimize the prototype PFAG vaccine construct and (II) conduct efficacy testing to confirm the optimal construct design. The long-term goal is to develop a peptide-based vaccine that can be used...
This Project Grant award of $293,142.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, aims to develop a rapid diagnostic test (RDT) in a lateral flow assay (LFA) format for detecting Babesia microti infection. The goal is to create a point-of-care test that can be used by both physicians and blood collection agencies to enable swift clinical diagnosis and prevent transmission through the blood supply. The project expands upon the awardee's previous work on an antigen capture ELISA targeting a Babesia secreted protein, with the intent of translating this technology into a user-friendly, highly sensitive RDT format. This award to L2 Diagnostics LLC, a for-profit biomedical research company based in Woodbridge, Connecticut, is intended to support the development of this critical diagnostic tool for addressing the increasing incidence of babesiosis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $293.1k | 9/21/25 |