Project Grant R43AI172560
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,013,468 to Inhalon Biopharma, Inc. to advance the development of IN-003PI, a passive immunization treatment against human metapneumovirus (MPV) infections. The funding will support key research activities such as producing GLP-compliant antibody batches, conducting IND-enabling toxicology and efficacy studies, and...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $433,175 to develop a mosaic mRNA vaccine to prevent hand, foot and mouth disease (HFMD). The goal is to create a broadly protective vaccine that can address the diverse viral strains that cause HFMD, which is primarily caused by human enterovirus serotype A viruses and can lead to severe complications like viral...
- The federal Project Grant award of $734,184.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the mechanism of genome replication for non-segmented negative-strand RNA viruses, including paramyxoviruses such as human parainfluenza virus type 3 (HPIV-3). The grant, awarded to Trustees of Boston University Medical Campus, aims to characterize the structure and...
- The University of Missouri System, under a $650,000 project grant from the USDA National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program, is developing safe and effective live attenuated swine influenza vaccines using Newcastle disease virus (NDV) as the vector. The project aims to address the challenges with current swine influenza vaccines, which often fail to provide cross-protection against diverse virus strains. The key products and...
- This Project Grant award of $458,250.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a VP4-based pseudovirus nanoparticle rotavirus vaccine for oral immunization. The award will fund research to create a non-replicating rotavirus vaccine candidate called S-VP4E, which consists of a calicivirus inner shell and multiple rotavirus spikes (VP4E) on the surface. This...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $308,669 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to Vishenary, LLC to develop a novel vaccine with broad efficacy against nontypeable Haemophilus influenzae (NTHI) strains following influenza A virus (IAV) infection. The project aims to create a vaccine candidate consisting of a conserved NTHI protein (Protein 0259) and the FDA-approved histone deacetylase inhibitor...
- The federal Cooperative Agreement award U19AI181984, totaling $44,108,652.00, was granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of this 3-year award is to develop vaccines and antibody-based treatments for viruses in the Paramyxoviridae, Peribunyaviridae, and Phleboviridae families, with a focus on prototype viruses such as human parainfluenza virus 3 (HPIV3), Oropouche virus...
- This $649,896 federal Project Grant awarded by the U.S. Department of Agriculture's (USDA) National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program supports the development and testing of an mRNA vaccine cocktail against influenza A viruses (IAV) in livestock. The project aims to create a universal influenza vaccine that can provide broad protection against diverse IAV strains, including highly pathogenic avian influenza (HPAI) H5N1...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to develop novel multivalent mucosal vaccines for human noroviruses. The total funding is $798,173 with a project period from May 1, 2025 to April 30, 2030. The key products and services to be delivered include: 1) Developing multivalent, live-vectored mucosal norovirus vaccines using FDA-approved rotavirus (RotaTeq)...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,968 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Viva Viral Vaccines, Inc. to develop a broad-spectrum, multivalent vaccine platform for pandemic and seasonal influenza. The platform leverages innovations in the production of influenza neuraminidase (NA) proteins in mammalian cells, enabling the development of VLP-based vaccines that can provide broad heterologous...
DEVELOPING A PIV5-BASED HUMAN METAPNEUMOVIRUS (HMPV) VACCINE - ABSTRACT IN THIS PHASE I SBIR APPLICATION, WE PROPOSE TO DEVELOP AN INTRANASAL, PARAINFLUENZA VIRUS 5 (PIV5)-BASED HUMAN METAPNEUMOVIRUS (HMPV) VACCINE. HMPV IS ONE OF THE LEADING CAUSES OF ACUTE RESPIRATORY INFECTIONS (ARIS) IN CHILDREN, IMMUNOCOMPROMISED INDIVIDUALS, AND THE ELDERLY. ILLNESS RANGES FROM ASYMPTOMATIC INFECTION TO SEVERE BRONCHIOLITIS AND PNEUMONIA, WITH 90-100% OF CHILDREN INFECTED BETWEEN THE AGES OF 5-10 YEARS OLD. NO LICENSED HMPV VACCINE IS AVAILABLE AND THERE IS AN UNMET MEDICAL NEED TO DEVELOP A SAFE AND EFFECTIVE HMPV VACCINE. PIV5 IS A SAFE DELIVERY VECTOR FOR INTRANASAL IMMUNIZATION. THE PIV5-VECTORED COVID-19 VACCINE (CVXGA1) AND RESPIRATORY SYNCYTIAL VIRUS (RSV, A LEADING CAUSE OF LOWER RESPIRATORY TRACT INFECTION IN INFANTS AND ELDERLY) VACCINE ARE CURRENTLY IN PHASE 1 CLINICAL TESTING. PRECLINICAL DATA FOR PIV5-BASED RSV CANDIDATE VACCINES HAVE SHOWN EXCELLENT IMMUNOGENICITY, PROTECTION, AND SAFETY PROFILES IN VARIOUS ANIMAL MODELS, INCLUDING THE COTTON RAT MODEL, DEMONSTRATING LACK OF VACCINE-INDUCED ENHANCED DISEASE OBSERVED FOLLOWING FORMALIN-INACTIVATED RSV VACCINATION. IN THIS GRANT PROPOSAL, WE WILL PRODUCE TWO PIV5-BASED HMPV CANDIDATE VACCINE CONSTRUCTS, ONE IN THE W3A STRAIN WITH THE SH GENE DELETED (W3A ! SH-HMPV-F) AND ANOTHER IN THE CANINE PARAINFLUENZA VIRUS (CPI) VACCINE STRAIN (CPI-HMPV-F) TO COMPARE THEIR REPLICATION IN VITRO, ANTIGEN EXPRESSION IN VITRO, IMMUNOGENICITY, AND PROTECTION AGAINST HMPV CHALLENGE INFECTION IN A MOUSE MODEL. THE NOVELTY OF THE VACCINE PROPOSED IN THIS PHASE I SBIR APPLICATION RELATES TO: 1) THE USE OF A CHIMERIC HMPV F PROTEIN CONTAINING THE PIV5 F CYTOPLASMIC TAIL TO POTENTIALLY INCREASE HMPV F ANTIGEN EXPOSURE ON THE VIRION SURFACE 2) A NEEDLE-FREE INTRANASAL DELIVERY METHOD IN A SAFE, HIGHLY IMMUNOGENIC VIRAL VECTOR AND 3) THE ABILITY TO INDUCE MUCOSAL IMMUNITY, WHICH IS NECESSARY FOR PROTECTING AGAINST RESPIRATORY PATHOGENS. ONCE THE PIV5-VECTORED HMPV VACCINE IS DEMONSTRATED TO BE IMMUNOGENIC IN THE MOUSE MODEL, THE PHASE II SBIR PROPOSAL WILL FOCUS ON PRECLINICAL STUDIES NEEDED FOR ENTERING PHASE 1 CLINICAL TRIALS WITH THE FINAL GOAL OF GENERATING A BIVALENT PIV5- VECTORED RSV AND HMPV VACCINE WHICH WOULD PROVIDE PROTECTION AGAINST THE TWO LEADING CAUSES OF LOWER RESPIRATORY TRACT INFECTIONS IN INFANTS AND ELDERLY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/16/25 | ||
| Not listed | $250.0k | 5/5/23 |