Project Grant R43AI152650
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $165,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Tufts University School of Medicine to develop an improved transposon mutagenesis system for comprehensive genetic analysis of Borrelia burgdorferi, the bacterium that causes Lyme disease. The project, running from July 1, 2025 to June 30, 2027, aims to create a high-efficiency transposon insertional mutagenesis system...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $207,262 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in Saint Louis to develop an mRNA vaccine against Bourbon virus, an emerging tick-borne pathogen. The primary objective is to evaluate the efficacy of the mRNA vaccine in a mouse model and determine its mechanism of action. A secondary objective is to test different viral antigens and...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $417,845 to the University of Nebraska Medical Center (UNMC) to adapt an in vitro human skin model for tick feeding to study transmission and colonization of the Lyme disease pathogen Borrelia burgdorferi. The 2-year project aims to: 1) Increase tick feeding efficiency and demonstrate transmission/acquisition of...
- This Project Grant award of $457,875.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to elucidate how the alternative sigma factor RpoS regulates gene expression in Borrelia burgdorferi and contributes to the persistence of the Lyme disease spirochete in the mammalian host. The key objectives are to 1) interrogate individual RpoS-regulated genes throughout the course...
- This federal Project Grant award for $640,129 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to decipher the regulatory networks of Borrelia burgdorferi (the bacteria that causes Lyme disease) as it transitions between tick vectors and mammalian hosts. The research aims to understand how the RpoS regulatory pathway controls gene expression to enable B. burgdorferi's dual-host lifestyle. Key objectives...
- The U.S. Department of Agriculture's (USDA) National Institute of Food and Agriculture (NIFA) awarded a $800,000 Project Grant under the Agriculture and Food Research Initiative (AFRI) program to Washington State University (WSU). The grant aims to develop a vaccine against anaplasmosis, a prevalent tick-borne infection in cattle that causes significant morbidity and an estimated $300 million in annual economic losses in the U.S. The project will test the protective capacity of outer membrane...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is providing $3,315,179 to Tufts University School of Medicine in Boston, Massachusetts to conduct research on the microbial determinants of excessive inflammation and severe Lyme disease. The research aims to systematically delineate the immunogenic lipoproteins of the Borrelia burgdorferi bacterium and ascertain their...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $423,106 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M AgriLife Research. This 2-year project, with a start date of August 1, 2025, aims to characterize the roles of tick inhibitors of metalloproteases in the transmission of the Lyme disease agent by blacklegged nymphal ticks. The research will involve unveiling the protease inhibition profiles of these tick...
- This $431,750 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will fund a 2-year research project to develop a "Basic Immunological Toolbox for Genus Peromyscus, Infection Tolerant Reservoirs of Zoonotic Agents". The project will focus on the white-footed deermouse (Peromyscus leucopus) and deer mouse (Peromyscus maniculatus), which are natural...
- The U.S. Department of Agriculture's National Institute of Food and Agriculture (NIFA) awarded a $599,455 Project Grant under the Small Business Innovation Research (SBIR) Program (CFDA 10.212) to VST LLC (DBA Medgene Labs) located in Brookings, SD. The purpose of this 2-year grant is to develop the first U.S.-based vaccine against the invasive Asian Longhorned Tick, which poses a major threat to animal health and productivity in cattle and other livestock. The vaccine will be...
LOW-COST PRODUCTION OF A VACCINE FOR LYME DISEASE IN MAIZE - PROJECT SUMMARY/ABSTRACT IN KEEPING WITH THE NIH'S STATED PRIORITY FOR THE DEVELOPMENT OF VACCINES TO BACTERIAL ZOONOSES, OUR GOAL IS TO DEVELOP AN EFFECTIVE AND CONVENIENTLY DELIVERED VACCINE TO PROTECT AGAINST THE SPIROCHAETE, BORRELIA BURGDORFERI, THE CAUSATIVE AGENT OF LYME DISEASE. THE BACTERIUM IS VECTORED BY INFECTED IXODES SPECIES TICKS BETWEEN HUMANS AND MAMMALIAN RESERVOIRS. OUR CHOSEN ANTIGEN CANDIDATE IS OSPA, A SURFACE PROTEIN WHICH PRESENTS AS THE SPIROCHAETE TRANSITS BETWEEN THE ARTHROPOD VECTOR AND THE MAMMALIAN HOST. VACCINATION WITH THIS ANTIGEN ALLOWS PROTECTIVE ANTIBODIES TO ENCOUNTER THE SPIROCHAETE WHILE STILL INSIDE THE TICK AS IT ENGORGES WITH A BLOOD MEAL, AND HAS BEEN SHOWN TO BE EFFECTIVE AS A TRANSMISSION BLOCKING VACCINE. IN ORDER TO DEVELOP ADEQUATE AMOUNTS OF ANTIGEN FOR AN EFFECTIVE AND ADEQUATE IMMUNE RESPONSE, WE HAVE ESTABLISHED A PROPRIETORIAL EXPRESSION SYSTEM USING RECOMBINANT MAIZE. AN ADDITIONAL ADVANTAGE OF MAIZE EXPRESSION IS THAT VACCINE ANTIGENS CAN BE DIRECTLY ADMINISTERED THROUGH THE ORAL ROUTE RATHER THAN PURIFIED FOR INJECTION. IN THIS PROPOSAL, OUR GOAL IS TO PRODUCE LARGE AMOUNTS OF OSPA ANTIGEN CANDIDATE IN MAIZE, ORALLY ADMINISTER THE ANTIGEN TO MICE IN FEED FORMULATED FROM RECOMBINANT MAIZE FLOUR, AND DEMONSTRATE THAT THE ANTIGEN ELICITS A PROTECTIVE IMMUNE RESPONSE AGAINST CHALLENGE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/28/24 | ||
| Not listed | $310.7k | 2/23/22 | ||
| Not listed | $310.7k | 2/23/22 | ||
| Not listed | $282.9k | 3/2/21 | ||
| Not listed | $282.9k | 3/2/21 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
R43AI152650S | Immuno Technologies Inc. | Project Grant R43AI152650 | $55.0k | 3/2/21 |