Project Grant R43AI145593

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a 3-year, $450,000 Project Grant to The Washington University to develop a novel "Plasmon-Enhanced Expansion Fluorospot" (PEEFS) technology. This bioplasmonic imaging method combines fluorescent nanoparticles and expansion microscopy to enable highly sensitive and high-resolution monitoring of cell-secreted proteins at the single-cell level. Key project objectives...

This $305,000 STTR Phase I Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop an ultra-sensitive biosensor capable of protein analysis at single-molecule resolution. The biosensor consists of a nanopatterned chip with a proprietary scaffold material that binds and immobilizes molecular targets, which are then detected using surface-enhanced Raman spectroscopy (SERS). This innovation seeks...

This $295,308 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development and validation of a novel class of scanning probe microscopy (SPM) probes for rapid identification of infectious disease agents. The awardee, Actoprobe LLC, aims to dramatically improve the sensitivity and spatial resolution of scanning...

This $160,260 National Science Foundation Project Grant from the Division of Electrical, Communications and Cyber Systems will support the development of a novel on-chip dual polarization interferometry technique and circuit implementations to enable an electrically driven and electrically readout low-cost silicon nanophotonic biosensor. The University of North Texas will collaborate with the University of Dayton to employ state-of-the-art photonic device fabrication at a 300mm CMOS foundry to...

The Regents of the University of California at Riverside received a $456,000 project grant award from the National Science Foundation on August 1, 2021 to develop high-performing nanoplasmonic biosensors with novel thin films and metasurfaces. The project aims to advance progress in the mathematical and physical sciences through the creation of new sensing technologies under the NSF's Mathematical and Physical Sciences program (CFDA 47.049). By leveraging nanophotonics and nanofabrication...

This federal Project Grant award for $412,276 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of an optofluidic biosensor using an integrated waveguide spectrometer. The key objectives are to: 1) demonstrate detection of individual nanoparticles on an integrated multi-mode interference (MMI) waveguide spectrometer optimized...

This $147,091 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project on plasmonic nanoantenna-enhanced fluorescence immunoassay enabled by super-hydrophobic surfaces. The goal is to develop a transformative fluorescence detection technology that can achieve ultra-low and ultra-sensitive protein detection, which is crucial for early disease diagnosis. The project...

This STTR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on developing highly sensitive, room-temperature, single-photon detectors based on plasmonic metasurface coherent optical detection technology. The $304,987 award to Clearview Optics LLC aims to address the need for ultrasensitive optical detectors and ranging systems to enable improved information acquisition and perception...

This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...