The National Institute on Aging (NIA) awarded a $295,923 Project Grant (CFDA 93.866 - Aging Research) to Larix Bioscience LLC to develop novel hormonal therapeutics and study their efficacy with adult stem cells for the treatment of chronic pressure ulcers. The project aims to generate stable, bioactive hormone fusion biologics and evaluate their ability to enhance tissue regeneration in pressure ulcer patients, both alone and in combination with adipose-derived or induced pluripotent stem...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), aims to develop a novel therapeutic approach to improve angiogenesis and wound healing by delivering apoptotic neutrophils within a degradable hydrogel scaffold. The $172,700 award, effective August 20, 2024 through July 31, 2026, supports research to investigate the effects of the hydrogel-apoptotic neutrophil delivery on macrophage angiogenic signaling and its impact...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $299,428 Project Grant to WNT Scientific LLC to develop an innovative medical device to treat nonunion fractures in older adults. The device is a biodegradable, controlled-release material designed to promote fracture healing by stimulating angiogenesis (blood vessel formation), which is impaired in elderly patients due to chronic inflammation. The awarded project aims to commercialize this...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rhaeos, Inc. provides $613,044 to develop wearable sensors for continuous, non-invasive monitoring of chronic wounds in older adults. The goal is to create a biomedical device that can track key wound healing biomarkers like temperature and moisture balance in real-time, without disturbing the wound with frequent dressing changes required by current assessment methods. This technology aims to enable...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a hyperstable and bioactive FGF1-FGF2 dimer formulation for effective healing of diabetic skin wounds. The $435,226 award to the University of Arkansas will fund research activities across three key objectives: Designing a hyperstable and bioactive FGF1-FGF2 dimer and its variants, Developing injectable anionic...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $500,000.00 to Alzarrok Bio LLC to develop a peptide-based multi-target drug for Alzheimer's disease (AD). The goal is to demonstrate the in vivo efficacy of the drug candidate, ALZ100, in inhibiting neuroinflammation and neurodegeneration in an AD mouse model. The project will first determine the therapeutic concentration of ALZ100 in the brain and then evaluate its effects on key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $713,096 to Minnesota Healthsolutions Corporation to develop an innovative chair with a calibrated pressure-shifting programmable surface. The goal is to prevent and treat pressure injuries in persons living with Alzheimer's disease or related dementias (ADRD). The project will involve testing the effectiveness of the chair in shifting pressure, as well as assessing its acceptability and...
This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research into the roles of the epidermal integrin α3β1 in age-related changes during cutaneous wound healing. The $607,398 award to Albany Medical College will fund a two-year research project to investigate how age-related decreases in the expression and function of the α3β1 integrin on...
This Project Grant award of $305,000 from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development of an advanced wound care product for treating diabetic foot ulcers. The product utilizes a patented microneedle patch design to deliver three therapeutic agents that disinfect the wound, prevent bacterial biofilm formation, and activate the immune system to promote healing. Initial work will be conducted using skin tissue...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $499,883 to Degrome Therapeutics, Inc. to develop small-molecule degraders of the amyloid precursor protein (APP) as novel therapeutics for Alzheimer's disease (AD). The project aims to optimize lead APP degrader compounds to improve their potency, solubility, and blood-brain barrier permeability, with the goal of identifying the most promising candidates for further development and evaluation...