This $295,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports Neurogeneces, Inc., a small business, in developing a machine learning algorithm to assess "brain age" from at-home EEG sleep data. The goal is to provide an objective, interpretable measure of age-adjusted brain function that can facilitate early detection of cognitive decline. Through this Phase I Small Business Technology Transfer (STTR) project, Neurogeneces will...
This Project Grant award from the National Institute on Aging (Federal Grant Program CFDA 93.866 - Aging Research) totaling $698,870.00 will support research to investigate the effects of thalamic stimulation on sleep oscillations in humans. The key products and services to be delivered under this award include: Studying the spatial extent of thalamic stimulation-evoked spindles and the disruption of spindles through real-time closed-loop stimulation in 50 patients with medication-refractory...
This federal Project Grant award, R01AG087163, in the amount of $780,466.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant aims to develop digital biomarkers using single-channel sleep electroencephalography (EEG) to monitor brain health and detect preclinical neurodegeneration, with a focus on Alzheimer's disease. The research team, led by the University of Colorado-Denver, will utilize over 15,000 sleep recordings from existing...
The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
This Project Grant award, valued at $134,730.00, was issued by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The goal of this project is to develop electroencephalogram (EEG) biomarkers to predict the future risk of dementia and monitor cognitive decline in older adults. The research will leverage existing datasets from the National Sleep Research...
This $1,955,041 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into the relationship between sleep, pericytes, and Alzheimer's disease pathology. The Medical University of South Carolina will investigate whether pericytes, cells that regulate cerebral blood flow and blood-brain barrier permeability, mediate the effects of sleep disruption on Alzheimer's disease progression. Specifically, the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $258,498.00 to the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
This $446,875 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate whether genetic risk variants for Alzheimer's disease have a pleiotropic effect on sleep duration and other sleep phenotypes. The research will involve two complementary approaches: 1) in silico bioinformatic analysis to identify potential shared genetic factors between Alzheimer's disease and sleep traits, and 2) functional studies in zebrafish to directly...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,000 in funding to Northeastern University to develop and apply new intravital microscopy techniques. The goal is to gain greater insight into the effects of gamma entrainment, a non-pharmacological neuromodulation technique, on cerebral energy metabolism and microvascular hemodynamics in Alzheimer's disease (AD) models. The project will nondisruptively characterize cellular-level changes to...