Automated system for accurate determination of activities of daily living for independently-living persons with alzheimers disease and related dementias

Ended Project Grant Awarded Last action

Award ID
R43AG076113
Recipient
Awarding agency
Obligated
$878,920

Award facts

Assistance listing
93.866 Aging Research
Completion date
Originally
Place of performance
Minnesota, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In this phase i sbir project, aster labs will develop and evaluate an innovative system to automatically and accurately detect activities of daily living (ADL) performed by persons with alzheimer's disease and related dementias. IT will address a current need to equip caregivers and health care providers, including physicians and cognitive rehabilitation therapists, with reliable information on patients' ongoing abilities to perform these important activities. The confirmation of these abilities will directly support the capability of a functioning independent lifestyle, while producing informed decisions on interventions and level of care based on disease progression. An estimated 5.8 million americans in 2020 live with alzheimer's dementia. Nearly a third of these individuals live alone and are more likely to experience poorer health outcomes than cohabitating persons. Ongoing assessment of ADL is highly recommended for establishing diagnosis of dementia and progression of the disease over time. Existing and proposed approaches to automate this assessment in the home have ranged from cameras or vision-based sensors to beacon-based signal processing techniques. However, these approaches have been subject to limitations and critique due to privacy concerns, poor accuracy, limited coverage, and requirements of significant infrastructure alterations. Common commercial activity trackers have concentrated primarily on fitness activities, and typically rely on non-discreet wearable devices that, due to unfamiliarity, may be unacceptable to dementia patients. Clinical research has indicated interventions involving compensatory memory techniques and devices may help prevent or delay dementia onset, and preserve functional independence. Use of both manual and digital memory notebooks to help patients record when they performed certain activities have shown significant promise. However, seniors with memory impairment and dementia may risk inaccurate recollection of activities performed throughout the day, and have faced difficulty interacting with recent digital implementations of these interventions. An unmet need exists in the ability of those caring for these individuals to receive verifiable information on whether the activity was completed at the time reported by the patient, or at all. Aster labs' proposed activlog system leverages intelligent processing of wifi, GPS, inertial, and audio sensor data from a small hardware suite concealed in a shoe insole, unnoticeable to the wearer, that uses high-precision location and multi-sensor association to accurately and continuously monitor and detect ADL. In phase i, the prototype system will be assembled, with feasibility demonstrated by functional evaluation conducted through a focus group study with caregivers, physicians, and cognitive rehabilitation therapists of patients with dementia. Activity classification accuracy of the device will be determined in timed experiments by aster labs' engineers wearing the prototype insoles. Phase i testing will provide the success criteria for the start of the phase II program, which will include a human study of the fully- operational system in home and independent living settings to establish the efficacy of this approach.

Transactions

Action Obligated Date
Amendment $0
Amendment $439,460
Original award $439,460

Subawards

Subrecipient Amount Awarded
University Of Florida Subaward effort on NIH program. Assist with user interface and report generation development. Perform human focus study evaluation for Phase II planning. $112,424

Quick answers

Who received award R43AG076113?

R43AG076113 was awarded to Aster Labs, Inc. by National Institute on Aging (National Institutes of Health) on September 1, 2022.

How much is award R43AG076113 worth?

$878,920 has been obligated on R43AG076113.

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