Project Grant R43AG056186

This Project Grant award, titled "Injectable Hydrogels for hiPSC-Neuron Therapy of Spinal Cord Injury", is funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The $504,888 award to The Leland Stanford Junior University aims to develop an engineered biomaterial that enhances the survival and integration of human induced pluripotent stem...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $810,596 to New York University School of Medicine to develop a novel chimeric antigen receptor (CAR) macrophage (MI) therapy for the treatment of Alzheimer's disease (AD). The key products to be delivered include: Optimizing the transdifferentiation of human induced pluripotent stem cells (hiPSCs) into self-sustainable macrophage/microglia (IMI) cells that can be engineered to express CARs...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $429,925 to Rosalind Franklin University of Medicine & Science to explore the use of glial progenitor cells for generating dopaminergic neurons as a potential cell therapy for Parkinson's disease. The research aims to directly reprogram adult human oligodendrocyte progenitor...

The National Institute on Aging (NIA) awarded a $295,923 Project Grant (CFDA 93.866 - Aging Research) to Larix Bioscience LLC to develop novel hormonal therapeutics and study their efficacy with adult stem cells for the treatment of chronic pressure ulcers. The project aims to generate stable, bioactive hormone fusion biologics and evaluate their ability to enhance tissue regeneration in pressure ulcer patients, both alone and in combination with adipose-derived or induced pluripotent stem...

This $598,952 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support the development of a novel human stem cell-derived multi-cellular model to study the developmental processes underlying spinal cord midline crossing of axons. The research team at The Leland Stanford Junior University will generate and characterize neural...

This $1,931,965 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research program) will fund the development and validation of a novel, human induced pluripotent stem cell (iPSC)-based model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, pericytes, and microglia. The goal is to create an advanced in vitro model with improved construct, face, and predictive validity for studying the cerebrovascular interactions relevant to Alzheimer's...

The federal Project Grant award R01AR085141, totaling $600,475.00 and awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop a collagen-based scaffold modified with specific integrin ligands and extracellular vesicles derived from placental mesenchymal stem cells. This scaffold is intended to synergistically recruit and guide endogenous stem cells for the...

This $4.4 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into developing a non-invasive stem cell-derived extracellular vesicle therapy for Alzheimer's disease. Over a three-year period from August 2022 to July 2025, researchers at Texas A&M University Health Science Center will test the hypothesis that intranasal administration of extracellular vesicles generated from human-induced pluripotent stem...

This $500,000 Project Grant awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports research to develop bioprinted tissue scaffolds with Schwann cell density gradients and electrical conductivity for peripheral nerve regeneration. The goal is to integrate electrical conductivity and neurotrophic growth factors with Schwann cell density gradients into scaffolds to enhance axonal regrowth for the treatment of peripheral nerve injuries. The research involves...

This Project Grant award with Federal Grant ID R21AR082992 was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $752,620 grant supports the development of injectable, cell-adhesive alginate hydrogels containing insulin-like growth factor 1 (IGF-1) mimicking peptides. The goal is to enhance the therapeutic potential of mesenchymal stem cells (MSCs) for repairing...