Project Grant R43AA022266

This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $148,568 to the University of California, Los Angeles (UCLA) to conduct research on the neuroepigenetic mechanisms underlying the transgenerational effects of alcohol exposure. The overarching goal of the research is to reveal the genetic and epigenetic programs that encode and transmit the memory of alcohol exposure across multiple...

This $317,534.10 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to understand the metabolic disruptions that lead to fetal growth deficits in prenatal alcohol exposure (PAE). The researchers at the University of North Carolina at Chapel Hill will quantify how alcohol alters maternal-fetal glucose and insulin signaling, with the goal of identifying the underlying mechanisms that...

This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), funded under the Alcohol Research Programs (CFDA 93.273), provides $399,293 to Echelon Biosciences Inc. to develop a prototype rapid point-of-care phosphatidylethanol (PEth) competitive lateral flow immunoassay. PEth is considered the most reliable long-term biomarker for detecting alcohol consumption, but current testing methods are costly and have slow turnaround times. The goal of this Phase I...

This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), focuses on investigating the role of choline-related genetic polymorphisms in modulating the impact of prenatal alcohol exposure (PAE) on cognitive and behavioral outcomes. The $479,164 award will fund a 5-year research study to: 1) Identify additional choline-related genetic variants that influence behavioral outcomes in individuals with...

This Project Grant award, titled "FAMILIES MOVING FORWARD BRIDGES: AN EARLY INTERVENTION ENHANCEMENT FOR INFANTS AND TODDLERS WITH PRENATAL ALCOHOL EXPOSURE WITH OR AT-RISK FOR FETAL ALCOHOL SPECTRUM DISORDERS", is funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award, totaling $231,364.00, will be used to examine the feasibility of implementing the FMF Bridges early intervention...

This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support the development of a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids. The platform will automate the maturation, maintenance, and assaying of over 100 brain organoids to create a robust, genetically diverse model for screening potential therapeutics for alcohol use disorder (AUD). The $499,987 award,...

This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a postmortem, multi-omic study of brains from 341 total subjects to identify novel lasting transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research will analyze RNA sequencing and whole-genome bisulfite sequencing data across 8 brain...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $412,125 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Research Foundation For The State University Of New York to study the impact of prenatal alcohol and methadone exposure on the regulation of dopamine signaling and synaptic plasticity in the basolateral amygdala. The two-year project aims to determine how the combined exposure to prenatal alcohol and methadone alters social and non-social...

This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, provides $187,143 to the University of California, San Diego to conduct a pilot study on patterns of alcohol and cannabis use before, during, and after pregnancy for both pregnant individuals and their partners. The key objectives are to: 1) characterize maternal and paternal patterns of alcohol and cannabis use over the course...

This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a clinical trial to evaluate the feasibility and efficacy of Trigeminal Nerve Stimulation (TNS) for treating prenatal alcohol exposure (PAE) in children. The $265,510 award will support a two-phase study. The initial R61 pilot phase will assess whether children with PAE can tolerate the TNS procedure, evaluate any safety issues, and...