Project Grant R42HL131081

This National Institutes of Health (NIH) R21/R33 grant award in the amount of $734,360 aims to develop and validate an innovative, inexpensive multi-modal digital stethoscope capable of automated lung sound and respiratory rate analysis, with mobile phone interoperability to an electronic health (eHealth) platform for real-time lower respiratory infection (LRI) and antibiotic surveillance in low- and middle-income countries (LMICs). The grant, awarded under the NIH's Child Health and Human...

This Project Grant award of $150,000.00, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), aims to develop a novel, non-invasive active sound sensing approach with artificial intelligence (AI)-based analysis of breathing sounds integrated on a smart pacifier device for real-time, continuous respiratory monitoring, particularly for neonates. The key products and services to be delivered under this award include: 1) Modeling a new...

This federal Project Grant award from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) provides $793,868 to Tufts Medical Center to develop and validate innovative machine learning methods for automating the diagnosis of aortic stenosis (AS) from cardiac ultrasound imaging. The goal is to improve the identification and treatment of this life-threatening cardiovascular condition that affects over 12.6 million adults annually in the...

This is a Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), for the development and implementation of a pediatric AI multi-modal digital stethoscope and respiratory surveillance system in South Africa. The $261,763 award aims to develop and validate an innovative, inexpensive multi-modal digital stethoscope capable of automated lung sound and respiratory rate...

This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $117,750 to the Ann & Robert H Lurie Children's Hospital of Chicago to develop and implement a remote patient monitoring dashboard that links parents' real-time vital sign data and symptom reports to pediatric patients' electronic health records. The goal is to facilitate more informed, remote adjustments to ventilator settings for children dependent...

This Project Grant award of $371,021 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a continuous respiratory monitoring platform to better classify apnea of prematurity (AOP) in premature newborns. The primary products to be delivered are: 1) a multimodal system and machine learning model to accurately detect and classify the major types of AOP (central, obstructive, and mixed); and 2) an optimized prototype system...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $269,922 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Steth X Microsystems Inc. to develop a smart, wearable contact microphone patch for extended and remote monitoring of lung functions. The goal is to create a low-profile, battery-powered wireless device capable of accurately detecting and quantifying adventitious lung sounds as well as breathing abnormalities in patients with respiratory...

This $188,136 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to develop an Artificial Intelligence-Enabled Echocardiography Interpretation System (AEIS). The principal investigator, Dr. Chieh-Ju Chao, will train with a multidisciplinary mentoring team led by Drs. Bradley Erickson and Fei-Fei Li to advance his skills in visual-linguistic models and large language models. The goal...

This Project Grant award of $781,129 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a 5-year study to validate and extend an integrated host-microbe (IHM) diagnostic approach for accurately diagnosing lower respiratory tract infections (LRTIs) in critically ill children. The study aims to: 1) validate the performance of the existing IHM LRTI diagnostic classifier, 2) develop a novel host gene expression...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $122,387 to the University of Colorado-Denver to conduct research on miR-301B and its impact on autophagy and cardiac function in pediatric dilated cardiomyopathy (DCM). The key objectives are to: 1) determine the expression levels of autophagy-related proteins in the heart tissue of pediatric DCM patients; 2) establish the effect of miR-301B overexpression on...