Novel tetrahedron beam CT for point-of-care imaging in ear, nose and throat imaging
Ended Project Grant Awarded Last action
- Award ID
- R42EB026401
- Recipient
-
Tetraimaging LLC UEI HFW2MYZMLMP6
- Awarding agency
-
National Institute of Biomedical Imaging and Bioenginering
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,889,130
Award facts
- Assistance listing
- 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health
- Completion date
- Originally
- Funding agency
- National Institute on Deafness and Other Communincation Disorders National Institutes of Health, Department of Health and Human Services
- Place of performance
- Missouri, USA
Award details come from USAspending.gov.
Description
- Abstract
- Point-of-care imaging is highly desired in otolaryngologic clinics for the diagnosis of ear, nose and throat (ENT) diseases including cancers. Due to limited image quality, current cone-beam CT (cbct) products act not as a substitute but rather as a complement to diagnostic multi-slice CT (msct) in maxillofacial and ENT imaging. The emerging multi-source x-RAY source technology suggests new designs of CT systems that may have faster imaging speed, improved image quality, reduced radiation exposure, and compact geometries. Tetrahedron beam computed tomography (tbct) is a compact volumetric CT based on linear array multi- pixel x-RAY sources which can produce diagnostic-quality volumetric images but in a much more compact geometry than cbct. During phase i study, we successfully developed a benchtop ENT-tbct system using a multi-pixel thermionic emission x-RAY (mptex) source developed in-house and a state-of-art commercial photon-counting detector (PCD), and demonstrated the superior image quality that tbct can achieve. During the phase II study, we will further refine the mptex source and develop a clinical prototype system. To achieve this goal, we propose to perform studies to achieve the following specific aims (SA): SA 1: to develop a rotatable sealed mptex source; SA 2: to develop a clinical ENT-tbct prototype on a rotating gantry; and SA 3: to develop advanced image reconstruction algorithm and perform benchmark imaging studies. The outcome of this research will be a highly effective point-of-care diagnostic imaging modality for otolaryngologic clinics. Future commercialization of the ENT-tbct system will improve the quality and efficacy by supporting prompt diagnosis and treatment of ENT cancers and other diseases.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $303,550 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $453,636 | |
| Amendment | $297,546 | |
| Amendment | $417,199 | |
| Original award | $417,199 |
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Quick answers
Who received award R42EB026401?
R42EB026401 was awarded to Tetraimaging LLC by National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) on September 30, 2018.
How much is award R42EB026401 worth?
$1,889,130 has been obligated on R42EB026401.
Which agency awarded R42EB026401?
National Institute of Biomedical Imaging and Bioenginering (National Institutes of Health) awarded R42EB026401, with funding from National Institute on Deafness and Other Communincation Disorders (National Institutes of Health).
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