This $600,534 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports the development of Link Biosystems Inc.'s bioreactor technologies to efficiently generate large quantities of "immunocompetent tumoroid tissues" from patient tumor samples. These tumoroid tissues will enable enhanced preclinical screening of cancer therapeutics, including immunotherapies, biologics, and drug combinations, to identify optimal treatment regimens tailored to specific patient populations. The bioreactor platform leverages controlled cell aggregation, low-shear perfusion, organotypic niches, and serum-free media to facilitate scalable expansion, differentiation, and maturation of various cell types while reducing costs and labor compared to conventional methods. This approach aims to address challenges in oncology drug development, where animal models often fail to predict human responses, by providing robust, reproducible, and clinically-relevant tumor models that incorporate immune and stromal components.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $55.0k | 9/12/23 | ||
| Not listed | $272.8k | 7/18/23 | ||
| Not listed | $272.8k | 7/18/23 |