An R2 non-neuroinvasive herpes simplex virus type 2 vaccine
Active Project Grant Awarded Last action
- Award ID
- R42AI177202
- Recipient
-
Thyreos Inc. UEI GFGNCMZKKLF7
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,288,038
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 86% complete
- Originally
- Place of performance
- Oak Park, IL 60302, USA
Award details come from USAspending.gov.
Description
- Abstract
- There is an unmet need for a herpes simplex virus (HSV) vaccine. We propose to develop a live-attenuated HSV-2 vaccine based on our R2 technology platform. R2 vaccines show unprecedented safety and efficacy in animal models, and offer antigenicity superior to subunit/mrna and single-round vaccine designs. R2 vaccines are also the first live-attenuated alphaherpesvirus vaccines that lack neuroinvasive potential, and thereby are incapable of establishing life-long infections in the nervous system. In phase I of this fast-track sttr application, we propose to: (I) produce a HSV- 2 self-excising infectious clone of a low-passage clinical isolate, (II) use the clone to produce a HSV-2 R2 recombinant, and (III) characterize the R2 vaccine in culture side by side with our existing HSV-1 R2 vaccine candidate. In phase II, the HSV-2 R2 vaccine will be tested for safety, immunogenicity, and efficacy in mice and guinea pigs. This work will provide the foundation to advance product development to clinical trials.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $703,683 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $663,123 | |
| Amendment | $663,123 | |
| Amendment | $663,123 | |
| Amendment | $297,493 | |
| Original award | $297,493 |
Quick answers
Who received award R42AI177202?
R42AI177202 was awarded to Thyreos Inc. by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on May 1, 2023.
How much is award R42AI177202 worth?
$3,288,038 has been obligated on R42AI177202.
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