Project Grant R42AG053149

This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provided $137,342.16 to Stanford University to develop generalizable deep learning networks for dual-tracer amyloid and tau positron emission tomography (PET) and magnetic resonance imaging (MRI) of Alzheimer's disease. Specifically, the university will validate the diagnostic value of convolutional neural networks (CNNs) in actual ultra-low-dose amyloid and...

Federal Grant Award Summary Massachusetts General Hospital received a $660,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on March 15, 2026, with a completion date of February 28, 2029. The award supports development of deep learning-based tools and methodologies to improve the accuracy and accessibility of Alzheimer's disease (AD) diagnosis through structural magnetic resonance imaging (MRI) analysis. Specifically, the project will develop...

Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $258,660 Project Grant (CFDA 93.866 – Aging Research program) effective June 15, 2025, through March 31, 2030, to develop and validate a machine learning-based framework for early detection and prognostication of Alzheimer's Disease and Related Dementias (ADRD). The project deliverables include the creation of a multi-modal biomarker integration system that combines digital biomarkers...

The National Science Foundation (NSF) awarded a $303,089 SBIR Phase I Project Grant to Bioimaginix LLC, a small business under the West Virginia University Research Corporation, to develop a low-cost artificial intelligence (AI) and machine learning (ML)-based diagnostic tool for early detection of Alzheimer's disease (AD) and mild cognitive impairment (MCI) using magnetic resonance imaging (MRI) brain scans. The goal of this project is to create an AI-ML platform that can accurately distinguish...

Grant Award Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $2.9M Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) awarded August 1, 2025, with completion targeted for April 30, 2030. This award supports the development of novel multimodal variational autoencoder (VAE) machine learning models designed to identify latent factors associated with cognitive resilience to Alzheimer's disease (AD) and AD-related...

Federal Project Grant Award Summary Boston University Medical Campus received a $323,825 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded January 1, 2026, with completion targeted for December 31, 2027. This award supports the development of advanced artificial intelligence (AI) tools and machine learning models designed to enhance early detection of Alzheimer's disease and related dementias (ADRD) using digital neuropsychological...

This Project Grant award of $4,787,820.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key objectives are to: 1) examine whether older adults experiencing...

This Project Grant award of $353,391.00, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to validate the use of a "Personal Learning Curve" paradigm as a sensitive marker of early memory decline related to Alzheimer's disease (AD) biomarkers in a large, diverse sample of older adults. The study seeks to determine if this digital cognitive assessment tool, which measures learning over repeated evaluations, can detect subtle AD-related memory failures...

This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...

Award Summary The National Institute on Aging awarded Brigham and Women's Hospital a $7.42 million Cooperative Agreement under the Aging Research program (CFDA 93.866) effective July 1, 2025, through June 30, 2030, to develop the Precision-AD Center. This initiative will establish a toolkit of two-dimensional and three-dimensional microphysiological systems (MPS) designed to model Alzheimer's disease and related dementias across genetically diverse populations. The project leverages induced...