Project Grant R41NS143513
- The National Institute of Neurological Disorders and Stroke awarded Aneuryst Inc. $492,110 on September 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds enzyme phenotyping of hydroxyfasudil to support preclinical development work for potential treatment of cerebral vasospasm following subarachnoid hemorrhage. The research advances foundational understanding of fasudil, a Rho-kinase inhibitor used in Japan for...
- The National Institute of Neurological Disorders and Stroke awarded Neurovascular Diagnostics Inc. $697,054 on September 16, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to test a blood-based assay for detection and risk assessment of intracranial aneurysms in familial cases. Neurovascular Diagnostics will validate AneuscreenTM, a PCR-based assay that uses gene expression in stabilized whole blood to predict both the...
- The National Institute of Neurological Disorders and Stroke awarded Patchclamp Medtech, Inc. $1,524,947 on July 27, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a novel medical device for sealing dural perforations in minimally invasive spinal and cranial surgery. Patchclamp Medtech will advance a Phase II prototype of an applicator system that delivers and secures a bioabsorbable graft-clasp assembly directly at...
- The National Institute of Neurological Disorders and Stroke awarded Barrow Neurological Institute at ST. Joseph's Hospital and Medical Center $464,514 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, R21NS145098) to conduct initial safety and target-site evaluation of MNP-05, a manganese-porphyrin-based superoxide-dismutase mimic, for subarachnoid hemorrhage treatment. The project addresses early and secondary...
- The National Science Foundation awarded Life Seal Vascular Inc. a $1.25 million cooperative agreement on August 1, 2026, to advance design and testing of the CygNum aneurysm sac management device for endovascular repair of abdominal aortic aneurysms. The recipient will optimize the device's delivery system, verify long-term biocompatibility, and demonstrate reliable performance in laboratory and preclinical models. The technical approach combines a compressible implant with precise...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh $587,678 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to elucidate immune cell trafficking and biodegradation of bioscaffolds implanted in brain tissue using multi-color 19F magnetic resonance imaging. The research visualizes the spatio-temporal dynamics of peripheral immune cell accumulation and invasion into...
- Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....
- The National Institute of Neurological Disorders and Stroke awarded Emory University $430,375 on June 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop x-ray dark-field imaging technology for carotid hemodynamic analysis using anisotropic iron oxide nanorods as contrast agents. The research addresses cerebrovascular disease assessment and plaque vulnerability prediction by advancing grating-based interferometric...
- The National Institute of Neurological Disorders and Stroke awarded Barrow Neurological Institute at ST. Joseph's Hospital and Medical Center $619,392 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate molecular mechanisms of early brain injury following aneurysmal subarachnoid hemorrhage, with particular focus on sex-based differences in patient outcomes. The award funds translational research that...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Wynnvision LLC $612,630 on September 25, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop an amine gradient silicone ventricular catheter for treating ventriculoperitoneal shunt infections and blockages. Wynnvision will translate successful in-vitro studies on amine gradient silicone Foley catheters to develop amine gradient silicone ventricular...
The National Institute of Neurological Disorders and Stroke awarded $435,979 to Aneuvas Technologies Inc. on September 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a novel biocompatible polymer coating for intracranial aneurysm treatment devices. The project will develop and optimize a polymeric coating (PPODA-QT) applied to nitinol flow diverters for endovascular aneurysm treatment. Current metal-based aneurysm devices are highly thrombogenic and require dual-antiplatelet therapy; the proposed coating aims to improve biocompatibility, eliminate thrombogenicity, and promote tissue regrowth for complete aneurysm neck repair. Work includes iterating on silane coating factors—concentration, chemical vapor deposition time, and vacuum pressure—to achieve uniform coatings on flow diverter prototypes developed in collaboration with Pivot Medical. Testing will occur under clinical guidance from Barrow Neurological Institute, leveraging bioengineering expertise and nano- and surface modification technology through the Center for Materials Interfaces in Research and Access. Performance occurs in Flagstaff, Arizona, with a period of performance from September 4, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $436.0k | 9/3/26 |