Project Grant R41NS135845
- This $999,998 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of Renerva LLC's Peripheral Nerve Matrix (PNM) technology. PNM is a tissue-based hydrogel derived from porcine nerve that aims to improve functional outcomes for patients with challenging peripheral nerve gap injuries. The Phase I project will optimize the PNM...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $310,834 to Clemson University to develop a nanoparticle-based platform for targeted, non-invasive delivery of therapeutics to the peripheral nervous system. The goal is to improve treatments for peripheral nerve injuries and diseases by overcoming the blood-nerve barrier that...
- This Project Grant award of $1,188,230 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to evaluate the cellular composition, activation state, and spatial niches involved in neuroma formation following severe peripheral nerve injuries. The primary goals are to validate preliminary data indicating that neutrophil extracellular traps (NETs) may be an...
- Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide...
- This Project Grant award of $567,037.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to characterize the synchrony between peripheral nerve post-injury activity and brain plasticity. The research will utilize an innovative optical imaging method to simultaneously monitor nerve regeneration and corresponding changes in the cerebral cortex in mice...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), has awarded a $500,000 Project Grant to Renerva LLC, a biomedical company in Swissvale, PA. The grant, funded under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279), supports the development of Renerva's PNM-CAP device - a novel, biodegradable nerve capping technology designed to prevent painful neuroma formation in peripheral nerve injuries and amputations. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $624,329 to Tulane University to develop an efficient delivery system for a painless nerve growth factor (NGF) variant to treat spinal cord injuries. The project aims to encapsulate the NGF variant in a nanotechnology platform for improved penetration into the central nervous system,...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $566,382 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Temple University. The 5-year grant, effective August 15, 2025, will support research to investigate novel therapeutic strategies for restoring sensory connections in the spinal cord after dorsal root injuries. The research aims to determine if specific subtypes of sensory axons prematurely...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $638,718 project grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Feinstein Institutes For Medical Research to conduct research on "Selective, Epineural Stimulation of Peripheral Nerves with Interferential Electrical Fields". The primary objectives are to: 1) Test the hypothesis that interferential current stimulation can selectively activate specific...
- This Project Grant award of $409,887.00 from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the mechanisms leading to small fiber neuropathy and loss of epidermal nerve fibers. The research aims to explore whether epidermal axons comprise a surveillance network that responds to threats on body surfaces, leading to nerve fiber density loss. Key areas...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $296,151 to Insoma Bio, Inc. to investigate the use of their proprietary Fractomer biomaterial to improve outcomes after peripheral nerve repair. The project aims to demonstrate that Fractomer, an injectable polypeptide scaffold, can provide the necessary mechanical support and well-vascularized microenvironment to enhance neuroaxonal regeneration following peripheral nerve injuries. The award period is from August 1, 2024 to July 31, 2025. If successful, this research could lead to the development of a new commercially viable product to address the significant clinical need and $7B market opportunity for improved treatments for peripheral nerve injuries.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $296.2k | 8/1/24 |