Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide ideal support for DMN procedures in vitro, and 2) determine the ability of PNM to accelerate and enhance functional recovery in a rodent DMN model. Successful outcomes have the potential to provide new treatment options for challenging peripheral nerve injury cases involving extensive muscle tissue loss, which are often associated with delayed repair and poor outcomes. The award supports Renerva's ongoing research to develop nerve repair matrices, nerve grafts/conduits, nerve caps, and related regenerative medicine products to restore muscular function and mobility for patients suffering traumatic or surgical peripheral nerve injuries.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $495.0k | 9/14/23 |