This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,038,154 to Spike Neuro LLC to develop a dual-function carbon-modified silicon microelectrode for simultaneous measurement of neurochemical and electrophysiological signals. The key objectives are to refine the carbon deposition process for silicon microelectrodes, optimize contact size, and evaluate longevity and function. The project will also...
This federal Project Grant award from the National Institute of Mental Health (NIMH), CFDA 93.242 Mental Health Research Grants program, provides $1,897,078.00 to Spikegadgets, Inc. to develop a commercialized platform for large-scale chronic electrophysiology. The key products and services to be delivered include: Commercializing a compact 512-channel integrated circuit called the "eCHIP" to enable multi-electrode array (MEA) manufacturers to integrate electronics directly onto...
The National Institute of Mental Health (NIMH) awarded a 2-year, $449,228 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for long-term electrophysiological profiling of human brain organoids. The project aims to 1) create a biological assay chamber supporting chronic electrophysiology while maintaining organoid health, 2) develop high-fidelity, 3D neural probes for chronic, extracellular...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) to Trustees of Dartmouth College in the amount of $517,546.00, with a project period from December 13, 2024 to October 31, 2029. The grant supports the development of a monolithic microelectrode array (MEA) probe that integrates electrical recording (electrophysiology) and fast-scan cyclic voltammetry (FSCV) capabilities for high-density neuromodulator sensing in behaving animal...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $606,548.00 to the University of Pittsburgh to develop a new brain recording technology called "mesoscopic electrophysiology." This innovative system will use a 3D grid of 1,920 intracranial electrodes to simultaneously record neural activity across an entire...
This $566,015 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), supports the University of Utah's development of a configurable and thermo-responsive intracortical electrode array platform using 3D printing and gallium-based liquid metal electrode materials. The goal is to create a next-generation implantable neural...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i) to develop a commercial instrument for large-scale, all-optical electrophysiology. The project aims to combine advanced optical techniques, including volumetric neural activity imaging and computer-generated holography, to enable simultaneous optical recording and manipulation of neuron activity across multiple...
The federal Project Grant award R43MH135817, totaling $383,553.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The funding supports the development and enhancement of a novel, minimally invasive system and procedure for non-surgical placement of electroencephalogram (EEG) electrodes in mice. This technology enables faster, more cost-effective EEG measurements in freely moving mice, which is highly valuable for...
Purdue University was awarded a $1,304,216 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to develop and test a new platform for high-density 3D electrophysiology and two-photon calcium imaging in freely moving animals. The goal is to enable simultaneous recording of millisecond electrical dynamics and spatial mapping of neural circuit activity during natural behaviors to better understand how the brain processes...
This $420,519 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to explore the use of temporal interference (TI) electrical neurostimulation as a non-invasive method for deep brain stimulation. The project aims to characterize the effects of TI on brain activity and functional connectivity using combined TI and fMRI in human subjects (Aim 1), and then apply TI to the dorsal anterior cingulate...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $233,825 to Spike Neuro LLC to develop a flexible carbon fiber penetrating nerve cuff and cortical array for neural recording, stimulation, and neurochemical detection. The goal is to create a highly flexible 3D penetrating array using carbon fiber technology integrated with Spike Neuro's proprietary polyimide surface arrays. The project aims to enhance the biocompatibility, conformity, and chronic stability of penetrating electrodes for electrophysiology recording and stimulation, which are critical for understanding and treating neurological disorders and mental health conditions. Key activities include modifying Spike Neuro's surface arrays to integrate carbon fibers, optimizing the array design, and conducting ex vivo testing in retinal tissue to evaluate the flexible array's performance. This 18-month award period runs from June 1, 2025 to November 30, 2026.