Project Grant R41MD021474
- Federal Cooperative Agreement Summary Asterion AI Inc. received a $1.25 million Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships program (CFDA 47.084), effective August 1, 2025 through July 31, 2027. The awardee will develop and validate an electroencephalogram (EEG)-based software product designed for pre-hospital stroke triage and detection of large vessel occlusion (LVO) strokes. The deliverables include expansion of a...
- The National Heart, Lung, and Blood Institute awarded Northwestern University $440,000 on September 1, 2026, under CFDA 93.837 (Cardiovascular Diseases Research) for the SPARTACUS project, a two-year effort to develop and validate an artificial intelligence tool that predicts stroke risk in atrial fibrillation patients taking anticoagulant medications. Northwestern will develop an advanced AI system called MIST-MAMBA that processes multiple data types—cardiac ultrasound, heart rhythm recordings,...
- The National Institute of Neurological Disorders and Stroke awarded $233,280 to the Regents of the University of Michigan on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to identify and address factors that delay acute stroke treatment delivery via telestroke. The project, titled "Understanding and Improving Acute Telestroke Care" and led by Principal Investigator Brian Stamm, MD, MSC, will characterize...
- The National Institute for Minority Health and Health Disparities awarded The University of Chicago $686,906 on April 17, 2026, under the Minority Health and Health Disparities Research program (CFDA 93.307) to develop machine learning and artificial intelligence tools for predicting out-of-hospital cardiac arrest (OHCA) risk at the community level. The award supports development of an OHCA risk score and virtual laboratory environment designed as decision support tools to help communities...
- The National Institute on Aging awarded Aster Labs, Inc. $499,943 on September 15, 2025, under the Aging Research program (CFDA 93.866) to design and construct a wearable gait-monitoring device for continuous home-based assessment of health decline in Black adults with Alzheimer's disease and related dementias. The device will measure gait patterns including stride and speed throughout the day to provide clinicians and caregivers with early indication of functional decline and disease...
- The National Heart, Lung, and Blood Institute awarded the University of Massachusetts Medical School $858,456 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, Assistance Listing R01HL184047) to develop and test an interoperable shared decision-making tool integrated into electronic health records for stroke prevention in atrial fibrillation patients. The project, titled DECIDE-AF, addresses suboptimal anticoagulation initiation and persistence among AF...
- The National Heart, Lung, and Blood Institute awarded Environment & Health Group Inc. $314,321 on August 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop HeartSense.AI, a generative AI-driven mobile health solution for hypertension self-management in lower-income adults. The application describes an mHealth platform that integrates a generative AI model with home-based blood pressure monitoring, digital pill reminders, and non-physician-led telehealth to...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $902,000 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop an abbreviated cardiovascular magnetic resonance imaging solution for time-efficient, cost-effective etiology diagnosis of acute ischemic stroke. The project develops a 10-minute abbreviated cardiovascular MRI protocol designed to identify the underlying cause of acute ischemic...
- The National Institute of Biomedical Imaging and Bioengineering awarded Weill Medical College of Cornell University $678,471 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a compact, portable transcranial Doppler ultrasound device for automated embolus detection in at-risk stroke patients. The funded work addresses the clinical gap in long-term, automated embolus monitoring outside clinical...
- The National Institute on Aging awarded the University of Maryland, Baltimore $649,688 on May 15, 2026, under the Aging Research program (CFDA 93.866) to develop microinstrumented cortical organoid therapy for chronic stroke treatment. The award funds research on brain organoid transplantation combined with flexible bioelectronic monitoring to enable real-time electrophysiology and intravital multiphoton imaging of implanted organoids in stroke-damaged adult brain tissue. Current stroke...
The National Institute for Minority Health and Health Disparities awarded Asterion AI Inc. $314,363 on August 5, 2026, under the Minority Health and Health Disparities Research program (CFDA 93.307) to develop and validate a pre-hospital electroencephalogram-based stroke classification system for rural emergency response. Asterion AI will deploy a CE-marked, FDA-cleared EEG system paired with machine learning models to differentiate ischemic from hemorrhagic stroke in the pre-hospital setting, operating within or alongside mobile stroke units and standard EMS. The system autonomously eliminates EEG artifacts and provides real-time stroke classification to accelerate treatment initiation. The underlying models achieve stroke-versus-non-stroke classification at an area under the curve (AUC) greater than 0.95 and large vessel occlusion detection at an AUC of 0.90. By enabling rapid ischemic/hemorrhagic differentiation before hospital arrival, the solution addresses the critical disparity in rural stroke outcomes: rural stroke patients are 50 percent less likely to receive intravenous thrombolysis and experience 8 percent higher mortality than urban patients, partly due to only 26 percent of rural residents living within a 30-minute drive of a certified stroke center. The grant supports Phase I research and development. Performance occurs in Dallas, Texas, with a period of performance through July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $314.4k | 8/7/26 |