Project Grant R41GM165131
- The National Institute of General Medical Sciences awarded Photothermal Spectroscopy Corp. $306,802 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a next-generation photothermal stimulated Raman scattering (PT-SRS) microscope for high-speed, label-free chemical imaging of live cells in standard multiwell culture plates. Current PT-SRS implementations use transmission geometries that prevent compatibility with inverted microscopes and...
- The National Institute of General Medical Sciences awarded N.p. Photonics, Inc., a Tucson, Arizona-based small business, $306,873 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to develop a low-cost robust compact 900 nanometer femtosecond laser source for two-photon microscopy, featuring ultrashort pulse lasers with peak powers exceeding 1 kilowatt and specified pulse durations. The award obligates $306,873 and runs through August 31, 2027,...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative...
- The National Institute of General Medical Sciences awarded Third Floor Materials, Inc. (3FM) $298,111 on September 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-throughput snapshot hyperspectral imager for multiplexed fluorescence microscopy. The system combines proprietary plasmonic filter arrays with backside-illuminated CMOS sensors to enable capture of complete hyperspectral datacubes—containing both spectral and spatial...
- The National Institute of General Medical Sciences awarded Molecular Instruments, Inc. $306,788 on September 30, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to advance probe technology for ultrasensitive RNA imaging via hybridization chain reaction (HCR). The project develops and refines in situ amplification methods based on HCR mechanism to overcome multi-decade limitations in RNA fluorescence in situ hybridization (RNA-FISH). Specifically, the work...
- This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Arlington $339,676 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop light-responsive osmium compounds as metallo-reagents for biomedical imaging and photoactivation. The project develops osmium-based...
- The National Institute of General Medical Sciences (NIGMS) awarded The Salk Institute For Biological Studies $475,249 on August 10, 2026, through the Biomedical Research and Research Training program (CFDA 93.859) to develop photon-efficient spectral lifetime microscopy technology. The award funds development of optical technology for multiplexed fluorescence imaging that combines fluorescence lifetime and spectral imaging approaches to increase the dimensionality of fluorescent signals. The...
- The National Institute of General Medical Sciences (NIGMS) at the Department of Health and Human Services awarded $420,093 to the Regents of the University of Michigan on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds a five-year investigation into how cells self-organize to sculpt tissue interfaces and generate the characteristic curvatures that shape organ architecture and function. The research takes a systems-level approach to...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $1,733,072 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multi-resolution open-top light-sheet expansion microscopy system. The project will advance 3D microscopy for high-throughput imaging of expanded tissues with ultra-high resolution—sub-150 nanometer...
The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded 37Degrees, Inc. $360,247 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type: Project Grant). The award funds development of photoacoustic microscopy systems for non-destructive, three-dimensional imaging of live and incubated engineered tissue. The project addresses a critical gap in tissue engineering manufacturing and quality control: existing optical imaging methods cannot characterize thick three-dimensional tissues, and traditional histological approaches are invasive, destructive, and do not permit real-time volumetric assessment or functional measurement such as vascularization and oxygenation status. Photoacoustic microscopy will enable quantitative, longitudinal characterization of tissue engineered medical products in both research and manufacturing contexts. 37Degrees, Inc., located in Chicago, Illinois, is the recipient. The period of performance runs from September 1, 2026, through August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $360.2k | 8/6/26 |