Project Grant R41GM162038
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $417,090.00 to the University of Virginia to develop a wireless, soft electronics-enabled smart microneedle patch for managing neck pain. The project aims to integrate electronic devices with thermo-responsive therapeutic microneedles to deliver effective pain relief while avoiding the side effects of oral medications. The funding supports the research and development of this novel transdermal...
- This Cooperative Agreement award of $1,278,689 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop an automated Neonatal Pain Monitoring System (NPMS) and pain management protocol to objectively measure and minimize postoperative pain in newborns. The project has two key objectives: 1) Develop and validate AI-driven neonatal pain biomarker signatures and an automated NPMS to continuously...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a Cooperative Agreement of $1,365,701 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop an automated machine learning algorithm called AUTOBPS for continuous monitoring of pain using facial expressions in the Intensive Care Unit (ICU) environment. The project, titled "Continuous Monitoring of Pain Using Facial...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $178,856 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research aimed at developing an interpretable and predictive model for post-surgical pain (P-SP) outcomes. The project will leverage multimodal data, including functional...
- This Project Grant award of $371,871 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund a biopsychosocial investigation into contemporary human models of postoperative pain. The project aims to gain a deeper understanding of the mechanisms underlying nociception and the pain experience in surgical patients. Key activities include examining endogenous pain modulation, pain neurocircuitry,...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This Project Grant, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is for the development of a system for automated pain behavior testing across preclinical disease models in rodents. The project aims to assess the commercial feasibility of this new behavior testing and analysis system for use in preclinical pain research. The total funding amount for this award is $305,000.00, with a start date of January 15, 2026 and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,910 Project Grant under CFDA 93.859 - Biomedical Research and Research Training program to Perfusio Corp. for the development of a "Multi-Spectral AI/ML Powered Burn and Wound Evaluation Technology Using a Cost-Effective Handheld Device". The project aims to create a portable, affordable, and user-friendly device that can provide real-time, dynamic physiologic data to medical providers for accurate assessment...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), provides $3,473,616 to the University of Connecticut to develop a novel implantable neuromodulation system called "SmartStim" to treat chronic pain. The goal is to create a combined device and drug treatment that can selectively block sensitized nociceptive (pain-sensing) nerve fibers, especially C-fibers, to reverse the underlying neural...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of PAIN VITALS, an AI-powered wearable physiological sensor system for continuous and objective monitoring of post-surgical pain. The $349,855 award to Aventusoft L.L.C., a minority-owned small disadvantaged business in Boca Raton, FL, will fund the design, development, and clinical testing of this innovative solution to address the ongoing challenge of effectively managing post-surgical pain. PAIN VITALS aims to provide clinicians with an objective pain index to help reduce the subjectivity in dosing analgesics, minimize the risk of overdosing or underdosing, and ultimately improve patient safety and outcomes during the post-operative recovery period.