Project Grant R41GM161305
- The National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training program (CFDA 93.859), awarded a $937,537 Project Grant to Scarab Genomics LLC to develop a continuous microbial fermentation system using reduced genome E. coli. The system will utilize programmed autolysis and nuclease production to enable more efficient manufacture of biopharmaceuticals. Key objectives include optimizing a lysis system for recombinant protein and plasmid DNA...
- The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $349,952 Project Grant on September 1, 2025 to Kano Therapeutics Inc. under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support research to develop an innovative non-viral method for nuclear delivery of DNA templates to address key limitations of current gene therapy approaches. The project aims to demonstrate proof-of-concept for using Kano Therapeutics' proprietary circular...
- The National Institute of General Medical Sciences (NIGMS) awarded a $298,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Epigenter, LLC in Providence, RI. The grant supports the development of "Epigenetic Editor Therapeutics" - a novel approach to modulating gene expression without altering the DNA sequence. The project aims to create recombinant, self-delivering epigenetic editor proteins that can be taken up by cells and targeted to...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $394,857 to the University of Nebraska to develop a system to protect and concentrate large DNA molecules for genome analysis. The project aims to: Develop an inverted insert to protect DNA during cell lysis. Develop a roadblock to concentrate chromosomal DNA. The goal is to create a method to protect and concentrate large DNA molecules...
- The National Institute of General Medical Sciences (NIGMS) awarded Epicypher, Inc. a $1,264,176 project grant under the Biomedical Research and Research Training federal grant program (CFDA 93.859) to develop a novel toolbox for studying how asymmetric post-translational modifications (PTMs) on nucleosomes regulate chromatin biology. The key products and services to be delivered include: A novel manufacturing method to efficiently generate asymmetric designer nucleosomes (A-dNucs) at...
- This $382,136 Project Grant was awarded on May 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The goal of this 5-year research plan is to define the engineering principles for designing programmable bioengineered multicellular structures (probioms) in prokaryotic cells as novel probiotic-based therapeutic applications. The award supports research by the University of Maryland,...
- This $314,000 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training program (CFDA 93.859). The grant was awarded to Cellfe, Inc. to optimize their CellFE microfluidic transfection platform for accelerated, scalable same-day sequential gene editing of T cells for allogeneic cell therapies. The project aims to enhance the speed, precision, and scalability of CRISPR-based gene...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $302,605.00 to Chimerna Therapeutics, Inc. to develop synthetic biology approaches for bio-orthogonal labeling of circular RNAs. The key objectives are to: 1) optimize a bacterial strain and expression conditions for high-efficiency amino functionalization of circular RNAs, and 2) produce a variety of...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- This Project Grant award of $147,486.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to reconstitute the synaptonemal complex (SC) of the nematode Caenorhabditis elegans in vitro using a bacterial protein expression system. The award recipient, The Johns Hopkins University, aims to use the purified SC components to study the molecular architecture and assembly mechanisms of this...
The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Chesapeake Genomic Systems, LLC, a biotechnology research and development company located in Halethorpe, Maryland. The grant, awarded on September 5, 2025, with a completion date of August 31, 2026, supports the development of a bacteria-free technology that generates synthetic circular supercoiled DNA (scsDNA). This technology aims to address critical bottlenecks in viral gene therapy production workflows by providing a scalable, synthetic approach to producing large DNA molecules that offer safety and efficiency advantages over traditional bacterial plasmid-based methods. The project's long-term goal is to establish an efficient, commercially viable, and abacterial workflow for producing DNA molecules larger than 10 kilobases in length, which are required for lentiviral gene therapy production.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.9k | 9/5/25 |