Project Grant R41GM159477

Award Date 6/5/25
Completion Date 5/31/26
Dollars Obligated $350K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
California, USA
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This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 to Cisterna Biologics, Inc. to develop a novel process for producing ultra-pure mRNA. The key products and services to be delivered include:

  1. Optimizing the use of cold-adapted (psychrophilic) RNA polymerases to minimize byproduct formation during in vitro transcription of mRNA, improving safety and efficacy for therapeutic use.
  2. Developing Cisterna's proprietary Specific Capture and Cleavage (SPECC) purification technology to completely eliminate contaminants from the mRNA.

The successful completion of this Phase I SBIR project, with an award date of June 5, 2025 and an ultimate completion date of May 31, 2026, will pave the way for a potential Phase II effort focused on scaling up manufacturing and validating the mRNA production platform in clinical settings. As the mRNA therapeutics market is projected to grow substantially, this award aims to establish Cisterna Biologics as a leader in high-quality mRNA production.

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