Project Grant R41GM139440

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund the design and preparation of diagnostic biomarker reference standards for mucopolysaccharidosis type I (MPS-I) and type II (MPS-II). These lysosomal storage disorders are included in newborn screening programs, but current first-tier enzyme activity screening has a high rate of false...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to advance the understanding of heparan sulfate (HS) biosynthesis and its role in cellular processes and disease. The $332,957 award to the University of Georgia Research Foundation will fund a 4-year research project to: Investigate the catalytic functions and substrate recognition mechanisms of the EXT1-EXT2 HS...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $444,830 in funding to the University of Florida to develop novel small molecule probes to study the precise function of the enzyme heparanase. Heparanase plays a key role in extracellular matrix (ECM) remodeling and regulating cellular processes, but its detailed mechanistic function remains elusive. This research aims to...

The National Institute of Standards and Technology (NIST), through its Congressionally-Identified Projects program (CFDA 11.617), awarded a $1,350,000 Project Grant to Michigan State University (MSU) to test the use of liquid chromatography-high resolution mass spectrometry (LC-HRMS) for isotopic profiling of carbon and sulfur isotopes in per- and polyfluorinated alkyl substances (PFAS). The primary goal is to develop an approach that can aid in source apportionment of PFAS contamination in...

This $290,986 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) aims to synthesize a comprehensive library of 38 structurally defined sulfated O-GalNAc glycans. The Sulfated Modular Synthesis/Enzymatic Assembly (SMSEA) approach will be used to create this glycan library, which will serve as an invaluable toolkit for functional glycomics research to advance the understanding of the...

This Project Grant award, totaling $780,034, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to develop new chemoenzymatic methods to synthesize infection-targeted positron emission tomography (PET) tracers from the common oncologic tracer 2-deoxy-[18F]-fluoro-D-glucose ([18F]FDG), with a focus on detecting Staphylococcus aureus (S. aureus) infections. The research team,...

The National Institute of General Medical Sciences (NIGMS) awarded a $228,000 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the West Virginia University Research Corporation. The objective of this 2-year project is to develop an automated, nanoscale-to-microscale capillary electrophoresis-based system to customize and produce standardized N-glycan structures. The proposed technology will utilize thermally reversible nanogels to sustain and integrate...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is intended to support research on the role of cell surface glycosaminoglycans (GAGs) in parathyroid hormone-related protein (PTHrP) signaling. The $242,310 award will be used to characterize the binding properties between PTHrP and heparin/heparan sulfate, as well as to determine the...

The National Institute of General Medical Sciences (NIGMS) awarded a $358,862 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small business, to develop a microfluidic SDS depletion electrophoresis (SDE) interface. This interface will enable direct coupling of capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) to mass spectrometry for improved characterization and quality control of monoclonal...

This Project Grant award from the National Science Foundation's Geosciences Program (CFDA 47.050) provides $624,780 to the University of California San Diego's Scripps Institution of Oceanography to continue its work in ensuring the quality control of oceanic carbon dioxide measurements globally. The key products and services to be delivered under this award from January 1, 2025 to December 31, 2027 include: Preparing and distributing at least 30,000 bottles of reference materials for key...