Project Grant R41DE034627
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $270,594 Project Grant to Greenmark Biomedical Inc. on Sep 1, 2025. The grant supports the development of nano-fluorapatite particles to directly fill subsurface enamel pores, with the goal of halting the progression of non-cavitated carious lesions without requiring multiple remineralization treatments. Preliminary data demonstrates the ability of...
- This $322,000 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support secondary data analysis from the CariesAway study to advance the implementation of school-based oral health programs using silver diamine fluoride (SDF). The research aims to explore the longitudinal caries arrest capabilities of school-based SDF applications, estimate surface-level caries risk...
- This $164,255 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to develop innovative methacrylate-based dental materials that can inhibit the formation of microbial biofilms to prevent secondary caries. The key objectives are to: (1) synthesize a new 2-aminoimidazole derivative, H10, and generate a methacrylate-based antimicrobial agent containing covalently conjugated...
- The federal Project Grant award in the amount of $613,736 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The grant was awarded to Cayman Chemical Co Inc., a for-profit company located in Ann Arbor, Michigan, to develop novel osteogenic small-molecule pharmacotherapies for dental bone regeneration. Specifically, Cayman Chemical will create novel EZH2 inhibitor...
- This $597,807 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will establish a novel 13C-labeled metabolite library for the study of dental caries. The key objectives are to: Create a 13C-labeled oral bacterial metabolite reference library for Streptococcus mutans and Streptococcus gordonii using SWATH LC-MS, with dual peaks identified and curated to improve rigor...
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- The University of Kansas Center for Research Inc. was awarded a $467,008 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to develop a novel non-invasive treatment for dental caries in children and patients with special needs. The project aims to create a biomimetic peptide-polymer interface that works synergistically with silver diamine fluoride (SDF) to arrest caries progression and...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $422,665 Project Grant to Oregon State University (OSU) to develop an integrated dental plaque bioanalytical platform for point-of-care diagnostics of oral diseases. The project aims to detect and quantify hydrogen peroxide and lactate produced by beneficial and pathogenic oral bacteria, and establish a correlation between oral caries...
This federal Project Grant award of $297,711.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop and test zinc tetraammine difluoride (ZAF) as a non-invasive, aesthetic, and cost-effective alternative to traditional dental caries management strategies. The objective is to determine the mineral loading efficacy of ZAF agents in human dentin, with the goal of providing ZAF as a practical solution for caries arrest and remineralization. The award was granted to Periomics Care LLC, a biotechnology company in New York focused on developing novel oral formulations for treating periodontal disease. The project has an initial completion date of July 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $297.7k | 8/6/25 |