The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $441,500 Project Grant (CFDA 93.121 Oral Diseases and Disorders Research) to the University of Colorado-Denver to develop uniquely high conversion and mechanically robust composite restorative materials for improved dental applications. The award aims to investigate the structure-property relationships and mechanisms that enable these novel polymer composites to achieve exceptional strength, toughness, and wear...
The National Institute of Dental and Craniofacial Research (NIDCR), through the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $959,035 project grant to the ADA Forsyth Institute, Inc. (The Forsyth Institute) to develop hydrolysis-resistant, multifunctional dental resin materials that surpass the performance and lifespan of existing methacrylate-based composites. The project aims to formulate new hybrid resin networks, incorporate antimicrobial and protein-repellent...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,539,292 project grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to the ADA Forsyth Institute, Inc. (The Forsyth Institute) to develop a novel operational platform and suite of multifunctional dental restoration materials. The key products and services to be delivered include: Creating a self-improving, universal dental adhesive that enhances its bond to tooth structure through...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
This Project Grant award of $408,375 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research on a novel biomimetic nitric oxide and hydroxyapatite (NO-HA) duo for advanced direct pulp capping. The research aims to develop a synergistic solution that can enhance bioactive and physical-mechanical barrier functions to support pulp-dentin repair and preserve tooth vitality. Key objectives...
The University of Kansas Center for Research Inc. was awarded a $467,008 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to develop a novel non-invasive treatment for dental caries in children and patients with special needs. The project aims to create a biomimetic peptide-polymer interface that works synergistically with silver diamine fluoride (SDF) to arrest caries progression and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multifunctional, 3D-printed dental implant capable of preventing peri-implantitis, a common and challenging implant-related oral infection. The $1,963,287 award to Cleveland State University will fund the development of silver-doped amorphous magnesium phosphate bioceramic particles, which will be incorporated...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,196,355 Project Grant (CFDA 93.121 Oral Diseases and Disorders Research) to Regendodent, Inc. in Ann Arbor, Michigan. The grant will support the development of REGENDOGEL (RG), a new class of dental material that stimulates regeneration of dental pulp and dentin damaged by decay or trauma. The project aims to compare the original RG formulation using bovine-derived dentin matrix molecules (DMMs) with a new...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $5,700,915 to the Regents of the University of Michigan to develop a new class of anti-caries therapy. The key products and services to be delivered include: Developing fluoride efflux inhibitors that potentiate the antimicrobial effects of fluoride and inhibit the growth of oral pathogens like Streptococcus mutans and...
This $1,999,789 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to advance oral health equity through strengthening the scientific basis for innovations in population approaches to improving dental care access, utilization, and quality. The research program will incorporate a framework that integrates multi-level perspectives and approaches (e.g., patient, provider, and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to develop high-performance, bisphenol A (BPA)-free dental restoration composites with remineralization capabilities. The $591,378 award was granted to Callentis Consulting Group LLC, a woman-owned small business in Austin, Texas, in collaboration with the University of Colorado and New Mexico State University. The research effort focuses on designing innovative urethane-based monomers as an alternative to the commonly used BIS-GMA resins, which can lead to health issues due to BPA leaching. The project will involve numerical modeling, experimental characterization, and evaluation of the feasibility and commercial viability of the proposed BPA-free dental composites, including assessment of their mechanical properties, remineralization potential, and cytotoxicity. The ultimate goal is to provide a high-performing, remineralizing dental restoration material that addresses major unmet needs in the estimated $20.2 billion global restorative dentistry market.