This $369,806 Project Grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into objective screening tests for noise-induced hearing damage. The University of Wisconsin-Madison will investigate short- and long-term changes in cochlear, afferent, and efferent auditory system function due to noise exposure using otoacoustic emission-based assays of the middle ear muscle reflex and medial olivocochlear reflex....
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $131,408.00 in funding to the Massachusetts Eye and Ear Infirmary to conduct research on the effects of noise-induced hearing loss on auditory cortex and amygdalar neural activity. The research aims to investigate how hearing loss can lead to maladaptive plasticity in the auditory...
The National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health (NIH), awarded a $131,555 Project Grant under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program to Oregon Health & Science University (OHSU). The project aims to characterize how noise-induced hearing loss (NIHL) affects the cortical representation and perception of complex natural sounds. Key objectives include: 1) Identifying the...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded Jacaranda Biosciences, Inc. a $304,762 SBIR Phase 1 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The funding will support the development of novel JBI compounds that function through the unfolded protein response (UPR) to prevent the ototoxicity and hearing loss caused by cisplatin chemotherapy treatment. The key objectives are to optimize the efficacy...
The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $358,245 Project Grant to the Massachusetts Eye And Ear Infirmary on May 15, 2024 for the project "IN SILICO SCREEN AND IN VIVO EVALUATION OF FDA-APPROVED DRUGS TO TREAT NOISE-INDUCED HEARING LOSS". The grant supports a two-year effort to screen FDA-approved drugs and evaluate the most promising compounds for their ability to protect against noise-induced hearing loss in cell...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $275,371 Project Grant (CFDA 93.173) to Auricle Health Inc. to develop an extracochlear device to restore hearing for patients with sensorineural hearing loss (SNHL). The funding will support refinement of the electrode design, demonstration of electrical stimulation of the cochlear nerve in animal models, and evaluation of the long-term safety and durability of the implant. This project aims to create a...
The National Institute on Aging (NIA) awarded a $262,975 Project Grant (CFDA 93.866 - Aging Research) to Kaiser Foundation Hospitals, through its Kaiser Foundation Research Institute division, to evaluate the associations of hearing loss with cognitive and brain health outcomes in middle-aged adults. The goal of this 2-year study is to clarify the relationships between midlife hearing loss and measures of cognitive function and brain aging, with a focus on potential disparities across race, sex,...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research on the genetic causes of adult-onset hearing loss. The $676,533 award to the University of Pennsylvania aims to elucidate the role of the ZNF175/ZFP719 gene in pathogenic mechanisms leading to hearing loss, including investigating its effects on auditory synapses, ion...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded the University of Southern California (USC) a $456,500 Project Grant (CFDA 93.173) to develop a novel diagnostic test for sensory hearing loss. The "Gain-Sensitive Cochlear Microphonics" (GCM) test aims to assess the functional state and site of damage within the cochlear amplifier, which is crucial for hearing sensitivity and range. The proposed research will validate the GCM test in mice by comparing...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to test the use of non-invasive, non-pharmaceutical mild therapeutic hypothermia (MTH) as a treatment for tinnitus. The $307,962 award to Restorear Devices LLC, a medical technology company based in Bozeman, Montana, will fund a clinical study to measure the effects of this experimental...