This federal Project Grant award of $1,006,428 from the National Institute on Aging under the Aging Research program (CFDA 93.866) supports the development of a targeted nanoformulation delivery system for curcuminoids to treat Alzheimer's disease (AD). The primary awardee, 3P Biotechnologies, Inc., will optimize exosome-based formulations of curcumin and bisdemethoxycurcumin, and evaluate their biodistribution and toxicity in wild-type mice. Additionally, the project will determine the efficacy of folic acid-functionalized exosomal curcuminoid formulations in AD mouse models, with the goal of enhancing targeted delivery to the brain using a novel trans-spinal administration route. The project aims to provide proof-of-principle for the effectiveness of this approach in modulating key molecular targets and cognitive function in AD progression, laying the groundwork for future Phase II dose-finding and intervention studies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $6.5k | 3/12/25 | ||
| Not listed | $500.0k | 9/20/24 | ||
| Not listed | $500.0k | 9/20/24 |