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All Federal Grant Awards
Project Grant R41AG062023
Award Date
9/30/18
Completion Date
5/31/21
Dollars Obligated
$741K
Overview
Activity
8
Transactions
8
Subawards
Similar Awards
Federal Agency
National Institute on Aging
Awardee
Sonica LLC (PV93CNTGRC46)
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Update #1
Update #2
A THERAPEUTIC WEARABLE SENSOR FOR DYSPHAGIA
Posted 9/22/18
5
1
2
Mod #
Description
ReasonForModification
Federal Obligation
Date
Not listed
CONTINUOUS MONITORING OF COVID-19 SYMPTOMATOLOGY FOR ELDERLY PATIENTS IN LONG TERM CARE FACILITIES USING ADVANCED, SOFT, AND FLEXIBLE SENSORS MOUNTED ON THE SUPRASTERNAL NOTCH - PROJECT SUMMARY: COVID-19 IS SIGNIFICANTLY MORE LETHAL IN THE ELDERLY1 WITH THE GREATEST RISK IN THOSE CARED FOR IN LONG-TERM CARE FACILITIES (LTCS) WHERE MORTALITY RATES RANGE FROM 19% TO 72% WORLDWIDE. MONITORING COVID-19 INFECTIONS IN LTCS REMAINS A PARTICULAR CHALLENGING. THE EXISTING AND A CONTINUED EXPECTED SHORTAGE OF SUFFICIENT MOLECULAR COVID-19 TESTING COUPLED TO FALSE NEGATIVE RATES AS HIGH AS 15% NECESSITATES A CRITICAL NEED FOR NEW AND COMPLEMENTARY TECHNOLOGIES THAT CAN SURVEIL, ALERT, AND TRACK COVID-19 INFECTIONS IN THIS POPULATION. OUR GROUP ARE PIONEERS IN THE DEVELOPMENT OF NOVEL SOFT ELECTRONICS. OUR RECENT PUBLICATION, SUPPORTED BY OUR ACTIVE PHASE I STTR, WAS PUBLISHED IN NATURE BIOMEDICAL ENGINEERING DETAILING A NEXT GENERATION ULTRA-LOW PROFILE, SOFT, AND FLEXIBLE SENSOR (ADAM) THAT CONTINUOUSLY MEASURES SUBTLE ACOUSTO- MECHANIC SIGNALS GENERATED BY THE BODY VIA AN EMBEDDED HIGH-FREQUENCY, 3-AXIS ACCELEROMETER IN DIRECT MECHANICAL COMMUNICATION WITH THE SKIN. THE ADAM SENSOR COMMUNICATES VIA BLUETOOTH WITH OUR CUSTOM MOBILE APPLICATION FOR REAL TIME STREAMING AS WELL AS ON SENSOR DATA STORAGE ENABLING STAND-ALONE OPERATION. ALL DATA STREAMS ARE CLOUD SYNCHRONIZED (HIPAA COMPLIANT). THE HIGHLY NOVEL SOFT, FLEXIBLE NATURE ALLOWS FOR THE ADAM SENSOR TO BE MOUNTABLE ON UNUSUAL LOCATIONS OF HIGH INFORMATION DENSITY. SPECIFICALLY, WE EXPLOIT THE SN-THE ONLY LOCATION ON THE BODY WHERE THERE IS NO DAMPENING EFFECT AT THE SKIN LEVEL WITH THE INTRATHORACIC CAVITY. THIS ENABLES A SN- MOUNTED ADAM SENSOR TO CAPTURE HEART RATE (HR), RESPIRATORY RATE (RR), TEMPERATURE, PHYSICAL ACTIVITY (PA), SWALLOW COUNT, AND TALK TIME, ALONG WITH ADDITIONAL NOVEL RESPIRATORY BIOMARKERS RELEVANT TO COVID-19. IN THIS PROPOSAL, WE PROPOSE TO DEVELOP A NEW COVID-19 SOFTWARE PACKAGE, MACHINE LEARNING ENHANCEMENTS TO OUR COUGH ALGORITHM, AND VALIDATION IN LTCS WITH BOTH ELDERLY PATIENTS AND STAFF TO EVALUATE USABILITY, FEASIBILITY, AND ADHERENCE. THE HIGH LEVEL OF TECHNOLOGY READINESS WITH PARTNER LTCS ALLOWS US TO DEPLOY EFFICIENTLY TO GENERATE ESSENTIAL DATA FOR A FUTURE FDA EMERGENCY USE AUTHORIZATION. OUR TEAM OF EXPERTS IN ENGINEERING, DERMATOLOGY, GERONTOLOGY, AND MACHINE LEARNING ARE HIGHLY QUALIFIED TO DEVELOP THIS COVID-19 SURVEILLANCE SYSTEM THAT OFFERS BOTH COMMERCIAL AND CLINICAL VALUE WITH BROAD APPLICABILITY TO A WIDE RANGE OF OTHER RESPIRATORY AND CHRONIC MEDICAL CONDITIONS AFTER THE PANDEMIC SUBSIDES.
$0
5/15/23
Not listed
A THERAPEUTIC WEARABLE SENSOR FOR DYSPHAGIA - 1 PROJECT SUMMARY: OF THE 42 MILLION INDIVIDUALS WORLDWIDE WITH ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD), 13% TO 57% (5.5 TO 24 MILLION INDIVIDUALS) SUFFER DYSPHAGIA OR SWALLOWING PROBLEMS. THE SEQUELAE OF DYSPHAGIA IN THIS VULNERABLE POPULATION INCLUDE MALNUTRITION, DEHYDRATION, AND ASPIRATION PNEUMONIA. SINCE SWALLOWING AND BREATHING SHARE A COMMON ANATOMICAL PATHWAY, PRECISE COORDINATION IS CRITICAL. IN NORMAL INDIVIDUALS, SWALLOWING OCCURS IN A WELL-REGULATED PERIOD BETWEEN MID-TO-LATE RESPIRATORY EXPIRATION, WHICH IMPARTS AIRWAY PROTECTIVE BENEFITS. IN DYSPHAGIA, THIS RESPIRATORY-SWALLOWING COORDINATION IS LOST. DESPITE THE HIGH PREVALENCE OF DYSPHAGIA IN INDIVIDUALS WITH DEMENTIA AND THE SERIOUSNESS OF THE CONSEQUENCES, THERE ARE LIMITED DIAGNOSTIC AND THERAPEUTIC MODALITIES AVAILABLE. THE CURRENT STANDARD OF CARE FOR DYSPHAGIA IN ADRD IS BEHAVIORAL SWALLOWING THERAPY WITH SPECIALLY-TRAINED SPEECH-LANGUAGE PATHOLOGISTS. SPECIFICALLY, OUR RESEARCH TEAM HAS RECENTLY PIONEERED A NOVEL CROSS-SYSTEM TRAINING APPROACH WITH 4-8 IN-CLINIC SESSIONS THAT DIRECTLY OPTIMIZES RESPIRATORY-SWALLOW TIMING (RST) THROUGH VISUAL BIOFEEDBACK. HOWEVER, THIS TRAINING MUST BE DONE IN-CLINIC AND REQUIRES LARGE, EXPENSIVE, BULKY, AND MULTI-WIRED SYSTEMS. CARRY OVER OF FUNCTIONAL IMPROVEMENTS IS IMPEDED BY THE ABSENCE IN-HOME TRAINING. NEW TECHNOLOGIES ADDRESSING DYSPHAGIA SPECIFICALLY ADRD REQUIRES SIGNIFICANT USER-CENTRIC DESIGN, STRAIGHTFORWARD OPERATION THAT IS DEPLOYABLE AT HOME WITH MINIMAL CARETAKER BURDEN, AND ROBUSTNESS. WE HAVE PREVIOUSLY DEVELOPED A SOFT, FLEXIBLE, AND FULLY WIRELESS THROAT-DEPLOYED WEARABLE SENSOR CAPABLE OF CONTINUOUSLY TRACKING RESPIRATION AND SWALLOWING. WE PROPOSE ADDING A VIBRATORY HAPTIC MOTOR TO ENABLE A HOME-BASED THERAPY THAT RECAPITULATES RST THERAPY AFTER THERAPIST TRAINING. THIS NEW THERAPEUTIC WEARABLE WOULD VIBRATE GENTLY TO STIMULATE SWALLOWING AT HOME AS A STRENGTHENING EXERCISE WHENEVER A MINIMUM THRESHOLD OF SWALLOWING IS NOT MET. IN ADDITION, THE DEVICE PROVIDES ADDITIONAL FEEDBACK THAT REINFORCES SAFE SWALLOWS PERSONALIZED TO THE WEARER'S UNIQUE EXPIRATORY CADENCE. FIRST, WE WILL CONDUCT FOCUS GROUPS TO ENABLE USER-CENTRIC DESIGN. THEN, WE PROPOSE TO VALIDATE THIS SENSOR IN A SMALL COHORT OF PERSONS WITH MILD AD (CLINICIAN DEMENTIA RATINGTM=1). FINALLY, WE WILL EVALUATE ACCEPTANCE OF THE SENSOR IN A SHORT HOME TRIAL. THIS PROPOSAL ALIGNS WITH NIA PRIORITIES FOR THIS RFA, WHICH AIMS TO DEVELOP ASSISTIVE TECHNOLOGIES THAT ARE INNOVATIVE, EFFICACIOUS, SCALABLE, AND LOW-COST
$0
9/15/21
Not listed
A THERAPEUTIC WEARABLE SENSOR FOR DYSPHAGIA - 1 PROJECT SUMMARY: OF THE 42 MILLION INDIVIDUALS WORLDWIDE WITH ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD), 13% TO 57% (5.5 TO 24 MILLION INDIVIDUALS) SUFFER DYSPHAGIA OR SWALLOWING PROBLEMS. THE SEQUELAE OF DYSPHAGIA IN THIS VULNERABLE POPULATION INCLUDE MALNUTRITION, DEHYDRATION, AND ASPIRATION PNEUMONIA. SINCE SWALLOWING AND BREATHING SHARE A COMMON ANATOMICAL PATHWAY, PRECISE COORDINATION IS CRITICAL. IN NORMAL INDIVIDUALS, SWALLOWING OCCURS IN A WELL-REGULATED PERIOD BETWEEN MID-TO-LATE RESPIRATORY EXPIRATION, WHICH IMPARTS AIRWAY PROTECTIVE BENEFITS. IN DYSPHAGIA, THIS RESPIRATORY-SWALLOWING COORDINATION IS LOST. DESPITE THE HIGH PREVALENCE OF DYSPHAGIA IN INDIVIDUALS WITH DEMENTIA AND THE SERIOUSNESS OF THE CONSEQUENCES, THERE ARE LIMITED DIAGNOSTIC AND THERAPEUTIC MODALITIES AVAILABLE. THE CURRENT STANDARD OF CARE FOR DYSPHAGIA IN ADRD IS BEHAVIORAL SWALLOWING THERAPY WITH SPECIALLY-TRAINED SPEECH-LANGUAGE PATHOLOGISTS. SPECIFICALLY, OUR RESEARCH TEAM HAS RECENTLY PIONEERED A NOVEL CROSS-SYSTEM TRAINING APPROACH WITH 4-8 IN-CLINIC SESSIONS THAT DIRECTLY OPTIMIZES RESPIRATORY-SWALLOW TIMING (RST) THROUGH VISUAL BIOFEEDBACK. HOWEVER, THIS TRAINING MUST BE DONE IN-CLINIC AND REQUIRES LARGE, EXPENSIVE, BULKY, AND MULTI-WIRED SYSTEMS. CARRY OVER OF FUNCTIONAL IMPROVEMENTS IS IMPEDED BY THE ABSENCE IN-HOME TRAINING. NEW TECHNOLOGIES ADDRESSING DYSPHAGIA SPECIFICALLY ADRD REQUIRES SIGNIFICANT USER-CENTRIC DESIGN, STRAIGHTFORWARD OPERATION THAT IS DEPLOYABLE AT HOME WITH MINIMAL CARETAKER BURDEN, AND ROBUSTNESS. WE HAVE PREVIOUSLY DEVELOPED A SOFT, FLEXIBLE, AND FULLY WIRELESS THROAT-DEPLOYED WEARABLE SENSOR CAPABLE OF CONTINUOUSLY TRACKING RESPIRATION AND SWALLOWING. WE PROPOSE ADDING A VIBRATORY HAPTIC MOTOR TO ENABLE A HOME-BASED THERAPY THAT RECAPITULATES RST THERAPY AFTER THERAPIST TRAINING. THIS NEW THERAPEUTIC WEARABLE WOULD VIBRATE GENTLY TO STIMULATE SWALLOWING AT HOME AS A STRENGTHENING EXERCISE WHENEVER A MINIMUM THRESHOLD OF SWALLOWING IS NOT MET. IN ADDITION, THE DEVICE PROVIDES ADDITIONAL FEEDBACK THAT REINFORCES SAFE SWALLOWS PERSONALIZED TO THE WEARER'S UNIQUE EXPIRATORY CADENCE. FIRST, WE WILL CONDUCT FOCUS GROUPS TO ENABLE USER-CENTRIC DESIGN. THEN, WE PROPOSE TO VALIDATE THIS SENSOR IN A SMALL COHORT OF PERSONS WITH MILD AD (CLINICIAN DEMENTIA RATINGTM=1). FINALLY, WE WILL EVALUATE ACCEPTANCE OF THE SENSOR IN A SHORT HOME TRIAL. THIS PROPOSAL ALIGNS WITH NIA PRIORITIES FOR THIS RFA, WHICH AIMS TO DEVELOP ASSISTIVE TECHNOLOGIES THAT ARE INNOVATIVE, EFFICACIOUS, SCALABLE, AND LOW-COST
$0
9/15/21
Not listed
CONTINUOUS MONITORING OF COVID-19 SYMPTOMATOLOGY FOR ELDERLY PATIENTS IN LONG TERM CARE FACILITIES USING ADVANCED, SOFT, AND FLEXIBLE SENSORS MOUNTED ON THE SUPRASTERNAL NOTCH
$0
8/26/20
Not listed
CONTINUOUS MONITORING OF COVID-19 SYMPTOMATOLOGY FOR ELDERLY PATIENTS IN LONG TERM CARE FACILITIES USING ADVANCED, SOFT, AND FLEXIBLE SENSORS MOUNTED ON THE SUPRASTERNAL NOTCH
$249.3k
8/25/20