This $369,868 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to investigate the functional role of mitochondrial transfer from nerves to breast cancer cells, and how this process impacts cancer metastasis and the generation of cancer stem cells. The project aims to use innovative lineage-tracing techniques to quantify the contribution of nerve-to-cancer mitochondrial transfer to the breast cancer metastasis cascade, and evaluate how these mitochondrial transfers influence cancer cell metabolism, therapeutic resistance, and recurrence. The award recipient is the University of South Alabama, which has established expertise in cancer biology research, biomedical sciences, and federal grant and contract work across multiple disciplines. The project period runs from Jul 2025 to May 2030, with the goal of elucidating the mechanisms underlying the nerve-cancer interface and developing new therapeutic strategies against highly innervated cancers.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $369.9k | 7/7/25 |