This Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports research to elucidate the spatiotemporal dynamics of the extracellular matrix (ECM) in response to platinum-based chemotherapy treatment in high-grade serous ovarian carcinoma (HGSC). The $584,081 award, effective May 12, 2025 through April 30, 2030, will enable Sanford Research, a non-profit biomedical research organization, to utilize innovative engineering approaches, metabolic labeling, super-resolution imaging, proteomics, and machine learning to investigate how platinum-induced ECM changes contribute to HGSC chemoresistance. The goal is to develop more effective ECM-targeted agents to mitigate chemoresistance and improve treatment outcomes for HGSC patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $584.1k | 5/12/25 |