The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,276,908 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to Bloodworks, doing business as Puget Sound Blood Center and Program, to conduct molecular and translational studies on hematologic disorders, specifically von Willebrand disease and sickle cell disease. The project aims to investigate the impact of von Willebrand factor fragments on hemostasis, as well as the role of oxidation-induced changes to lipids in the sickle erythrocyte membrane and plasma lipoproteins in the pathophysiology of vaso-occlusion. The research will utilize in vitro and in vivo approaches, including microfluidic techniques and intravital microscopy, to better understand the mechanisms of these disorders and identify potential biomarkers and therapeutic leads. The grant award period is from March 1, 2025, to February 28, 2032.
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