Project Grant R35GM166239
- The National Institute of General Medical Sciences awarded the University of Wyoming $123,687 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cell fusion and gene expression in the C. elegans epidermis. The research uses the C. elegans epidermal syncytium as an in vivo model system to uncover fundamental mechanisms of multinucleate cell formation and function. The work combines single-nucleus genomics, advanced microscopy, and...
- The National Institute of General Medical Sciences awarded West Virginia University Research Corporation $345,650 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural and mechanistic studies of receptor guanylyl cyclases, with research focused on elucidating ligand specificity and activation mechanisms of GC-B and GC-C subtypes. The research builds on previously determined cryo-electron microscopy structures of GC-A and extends...
- The National Institute of General Medical Sciences awarded Marshall University Research Corporation $147,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect G protein versus β-arrestin-mediated signaling pathways in the cannabinoid receptor 1 (CB1). The research develops and characterizes a phosphorylation-deficient CB1 receptor that cannot signal through β-arrestin but retains G protein signaling capacity, enabling distinction between...
- The National Institute of General Medical Sciences awarded the Board of Regents of Nevada System of Higher Education, operating as University of Nevada, Reno, $361,519 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms of AKAP-mediated signaling compartmentalization and functional diversity. Over the next five years, the research will determine how disease-associated anchor protein AKAP11 mediates distinct cell...
- The National Institute of General Medical Sciences awarded the University of Washington $388,750 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support mechanistic research on interindividual variability in drug pharmacokinetics and adverse drug reactions. The funded work addresses translational gaps between preclinical drug development and clinical outcomes through mechanistic in vitro studies, mass spectrometry-based proteomics, and in silico...
- The National Institute of General Medical Sciences awarded The Medical College of Wisconsin, Inc., a Project Grant totaling $566,169 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds development of novel site-directed spin labeling electron paramagnetic resonance (SDSL-EPR) technologies and application of these and other biophysical methods to elucidate molecular mechanisms of G protein-coupled receptor (GPCR) signaling selectivity and...
- The National Institute of General Medical Sciences awarded the University of Washington $397,158 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the biosynthesis, discovery, and biocatalytic production of halogenated nucleosides and nucleoside-sulfamates. The research will investigate biosynthesis pathways of natural product nucleoside analogs containing rare functional groups, with emphasis on identifying key enzymes involved in...
- The National Institute of General Medical Sciences awarded the University of North Carolina at Chapel Hill $470,963 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct enhanced sampling of intracellular protein interactions with G-protein-coupled receptors (GPCRs). The project develops computational methods to characterize the lifetime and dissociation kinetics of GPCR-G protein and GPCR-arrestin complexes using molecular dynamics simulation...
- The National Institute of General Medical Sciences awarded Brigham Young University $558,383 on July 1, 2026 under the Biomedical Research and Research Training program (CFDA 93.859) to optimize therapeutic protein pegylation by integrating coarse-grain molecular simulation with cell-free protein synthesis and site-specific functionalization. The work addresses a fundamental limitation in protein therapeutics: polyethylene glycol (PEG) attachment, which improves drug half-life and immune...
- The National Institute of General Medical Sciences awarded the University of Utah $500,500 on March 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply nicotinic acetylcholine receptor targeted peptides for biomedical research. Over the five-year performance period through December 31, 2030, the University of Utah will develop a library of selective probes targeting nicotinic acetylcholine receptor (nAChR) subtypes currently lacking selective...
The National Institute of General Medical Sciences awarded the University of Wyoming $349,483 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research unlocking the therapeutic potential of beta-arrestin isoform bias as a novel dimension of drug design targeting G protein-coupled receptors (GPCRs). The research program addresses how GPCRs, which regulate nearly every physiological process in the body, initiate three distinct signaling cascades following agonist binding: G protein activation, beta-arrestin 1 recruitment, and beta-arrestin 2 recruitment (the latter two being mutually exclusive). The work leverages a novel drug screen demonstrating that GPCR agonists can bias the relative recruitment of the two beta-arrestin isoforms, opening the possibility of designing pharmaceuticals with established or new therapeutic effects while minimizing deleterious side effects from undesirable signaling pathways. Current drug development efforts often fail to account for the distinct and frequently opposing roles these beta-arrestin isoforms play in disease models. The program aims to empower the research community to harness the full three-pronged GPCR signal transduction mechanism by incorporating beta-arrestin isoform selectivity into biased agonist design. Performance occurs at the University of Wyoming in Laramie, Wyoming. The award period runs from September 1, 2026, through April 30, 2031. This is a Project Grant, the assistance type supporting investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $349.5k | 8/14/26 |