Project Grant R35GM166193
- The National Institute of General Medical Sciences awarded Southern Methodist University $399,927 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of desiccation tolerance in anhydrobiotic organisms. The research deciphers how certain animals survive near-complete absence of water by identifying and characterizing protective molecules—specifically late embryogenesis abundant (LEA) proteins and small heat shock...
- The National Institute of General Medical Sciences awarded Duke University $523,255 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the mechanisms, regulation, and impact of transposon activation through the Project Grant mechanism (R35GM161651). The award funds fundamental research investigating how transposons—elements comprising nearly 50% of the human genome—are regulated and how they contribute to genome stability and...
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Dallas $435,875 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to investigate how tissue-specific progenitor cell fate is governed by mesenchymal progenitors and sympathetic neurons during adult tissue regeneration. The recipient will use the postnatal mouse...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Southern Methodist University $447,174 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support computational research on protein dynamics and chemical kinetics using generative artificial intelligence and advanced theoretical modeling. The research focuses on three major themes: protein allostery mechanisms,...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
- The National Institute of General Medical Sciences awarded The University of Texas Health Science Center at San Antonio $433,125 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into the spatiotemporal regulation of DNA metabolism pathways. The project examines how homologous recombination proteins are selectively activated and deactivated at DNA lesions and replication fork structures, with particular focus on tyrosine...
- The National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health within the Department of Health and Human Services, awarded the University of Texas at Austin $485,765 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a Project Grant (R35GM161701) investigating the interactions between homologous recombination and non-homologous end joining pathways in double-strand break repair in human cells. The research...
- The National Institute of General Medical Sciences awarded the University of Texas at Dallas $431,750 on February 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support five-year research into the mechanisms regulating kinetics and specificity of nuclear-cytoplasmic transport. The research addresses how nuclear pore complexes (NPCs) vary in number, post-translational modifications, and protein composition across cellular and developmental contexts, and how...
- The National Cancer Institute, within the Department of Health and Human Services National Institutes of Health, awarded The University of Texas Southwestern Medical Center $639,514 on June 1, 2026, for mechanistic characterization of NVL inhibition by benzothiazepinones as a non-genotoxic chemotherapy strategy under the Cancer Biology Research program (CFDA 93.396). The award funds research to define the catalytic mechanism of NVL, an essential AAA+ ATPase required for large ribosomal subunit...
- The National Institute of General Medical Sciences awarded Oklahoma State University $373,960 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on genome evolution and design in small, single-stranded DNA phages (Microviridae). The award is structured as a Project Grant with a period of performance running through August 31, 2031. Work is performed in Oklahoma City, Oklahoma. The National Institute of General Medical Sciences...
The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded Southern Methodist University $380,626 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into functional activation of P53 by reverse transcriptase processes, with emphasis on P53's role in suppressing retrotransposons—mobile genetic elements implicated in human disease. The investigator applies the Drosophila model to explore conserved P53 functions across the animal kingdom. Prior work demonstrated that wild-type P53 suppresses retrotransposon activity while cancer-patient-derived P53 mutants fail to do so, and that unrestrained retrotransposons appear in P53-driven mouse and human cancers. The funded studies will expand this research to determine the biological importance of P53-mediated transposon repression and establish the precise mechanisms involved, with the long-term goal of identifying novel entry points for understanding P53 in human disease and cancer prevention. Work is performed at Southern Methodist University in Dallas, Texas, with a period of performance through March 31, 2031. This is a Project Grant, the assistance type used by NIGMS for investigator-initiated basic research awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $380.6k | 7/30/26 |