Project Grant R35GM165579
- The National Institute of General Medical Sciences awarded $2,843,142 to Battelle Memorial Institute's Pacific Northwest National Laboratory on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a next-generation ultra-high resolution ion mobility spectrometer platform for metabolomics research. The project will deliver an ion mobility spectrometer with ultra-high resolution and sensitivity to detect small changes in metabolite structure, coupled...
- The National Institute of General Medical Sciences awarded $1.688 million to Pacific Northwest National Laboratory, a division of Battelle Memorial Institute, on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multimodal measurement platform for unambiguous lipid identification. The recipient will build a high-resolution ion mobility-mass spectrometry (IM-MS) system designed to distinguish free fatty acids and lipid isomers in complex...
- The National Institute of General Medical Sciences awarded the University of Washington $2,226,244 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanopore technology for single-molecule protein sequencing of intact proteoforms. The funded work advances unfoldase-coupled nanopore arrays to directly sequence native proteins at single-molecule resolution, detect post-translational modifications, and analyze complex proteoforms. The project...
- The National Institute of General Medical Sciences awarded the University of Washington $1,368,400 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop analytical tools for monitoring proline cis/trans isomerization in proteins. The recipient will develop tandem proteolysis combining cold liquid chromatography, proline-specific proteases, ion mobility mass spectrometry, and ultraviolet photodissociation to directly identify proline cis/trans...
- The National Institute of General Medical Sciences awarded Seattle Children's Research Institute $2.096 million on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an AI-driven platform for generating conditionally stable nanobodies for intracellular detection and protein manipulation applications. The project spans four years through April 30, 2030, and will deliver three core outputs. First, an expanded AI-based nanobody stability prediction...
- The National Institute of General Medical Sciences awarded Northeastern University $434,000 in Project Grant R35GM162269 on March 2, 2026, to develop integrated mass spectrometry strategies for characterizing metabolite-protein cross-regulation in cellular metabolism. The recipient will apply mass spectrometry-based methods to simultaneously probe metabolites and proteins in the cellular context, bridging a gap in current research that has typically focused on either metabolites or proteins...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $506,550 on September 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation single-cell multiomic methods for quantifying cellular identity and regulatory processes. The award funds development of a comprehensive suite of single-cell analysis technologies that simultaneously profile diverse regulatory processes—including DNA methylation,...
- The National Institute of General Medical Sciences awarded Partillion Bioscience Corp $979,071 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanovial kits for large-scale cell-cell interaction sequencing. Partillion will expand compatibility of nanovials—engineered hydrogel microcontainers that compartmentalize single-cell and cell-pair interactions—across widely used off-the-shelf single-cell sequencing chemistries to broaden user...
- The National Institute of General Medical Sciences awarded the University of Washington $380,371 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods that infer cellular history from single-cell sequencing data, enabling analysis of disease progression in tissues that cannot be sampled longitudinally, such as the brain in Alzheimer's disease or the heart in cardiomyopathy. The research deploys three integrated approaches:...
- The National Institute of General Medical Sciences awarded the University of Washington $2,102,360 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop ultrahigh multiplexing fluorescent probes and methods for spatial transcriptomics of tissue samples. The funded work encompasses design, synthesis, and characterization of over 1,000 spectrally and DNA-barcoded fluorescent probes conjugated with DNA oligonucleotide barcodes to enable single-molecule...
The National Institute of General Medical Sciences awarded Battelle Memorial Institute's Pacific Northwest National Laboratory $492,167 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-throughput multiomic platform for simultaneous single-cell profiling of proteins, transcripts, and metabolites. The platform integrates novel chemistry, advanced mass spectrometry, and automated nanodroplet processing to analyze thousands of individual cells. Central innovations include masked amino tags that double multiplexing capacity in mass spectrometry to enable analysis of up to 70 single cells per run, high-density nanodroplet arrays, automated droplet splitting for same-cell mRNA transcript capture, and ion-mobility-enhanced LC-MS for isobaric-labeled proteomic and metabolomic measurements. The project will deliver two new R packages—METABOR for metabolite quantification and COVARR for cross-modality covariation analysis—to integrate transcript, protein, and metabolite data. The platform will be applied to human peripheral blood mononuclear cells and pancreatic islet cells, with focus on amino acid signaling in immune activation and diabetes pathogenesis. Work is performed in Richland, Washington. The period of performance runs from August 15, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $492.2k | 8/13/26 |