Project Grant R35GM162519
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $506,550 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on compartmentalization and discrimination of double-stranded RNA in the nucleus. The funded research explores fundamental biological principles governing how cells distinguish self from non-self RNA molecules, specifically examining the balance between sensing pathogenic...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $363,191 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the role of non-canonical nucleic acid structures in genome regulation. The funded work investigates how non-canonical DNA structures—specifically R-loops (three-stranded RNA-DNA hybrid structures formed during transcription) and G-quadruplexes (four-stranded...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $591,549 in a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on June 1, 2026, to investigate how the Integrator complex and PP2A phosphatase regulate RNA polymerase II transcriptional integrity. The research addresses the molecular basis of RNA polymerase II pausing and pause-release mechanisms. The recipient will determine how the INT-PP2A module—which recruits the PP2A...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $506,550 under the Biomedical Research and Research Training program (CFDA 93.859) on April 1, 2026, to investigate mechanisms controlling the development of TIM4+ macrophages. The award funds a five-year research program (April 1, 2026 through March 31, 2031) conducted in Philadelphia, Pennsylvania. The research addresses how TIM4- macrophages develop into TIM4+ macrophages following their...
- The National Institute of General Medical Sciences awarded $406,250 to the University of Pennsylvania on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical and computational methods for analyzing complex multimodal biological datasets. The recipient will develop correlated latent factor models to extend multi-omic inference capabilities across complex study designs, including model-based imputation methods for handling missing data...
- The National Institute of General Medical Sciences awarded Worcester Polytechnic Institute $431,535 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate integrative machine learning methods for characterizing alternatively spliced isoforms of RNA-binding proteins and their functional roles in gene expression, RNA metabolism, and cellular homeostasis. The project will combine transcriptomic, proteomic, interactomic, and structural...
- The National Institute of General Medical Sciences awarded Imagen Bioworks Inc. $349,243 on September 12, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop SPOTLIGHT-OMICS, a scalable spatiotemporal-omics platform for pre-clinical drug discovery. The platform isolates disease-relevant cell subpopulations showing altered spatiotemporal phenotypes after drug exposure and subjects isolated cells to subsequent omics assays, linking cellular spatiotemporal...
- The National Institute of General Medical Sciences awarded the University of Washington $380,371 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods that infer cellular history from single-cell sequencing data, enabling analysis of disease progression in tissues that cannot be sampled longitudinally, such as the brain in Alzheimer's disease or the heart in cardiomyopathy. The research deploys three integrated approaches:...
- This $536,250 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports computational method development to advance single-cell transcriptomic data analysis. Awarded to Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, the project runs from July 1, 2025 through June 30, 2027 and develops knowledge-guided algorithms designed to improve the detection and...
- The National Institute of General Medical Sciences awarded Battelle Memorial Institute's Pacific Northwest National Laboratory $492,167 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-throughput multiomic platform for simultaneous single-cell profiling of proteins, transcripts, and metabolites. The platform integrates novel chemistry, advanced mass spectrometry, and automated nanodroplet processing to analyze thousands of individual...
The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $506,550 on September 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation single-cell multiomic methods for quantifying cellular identity and regulatory processes. The award funds development of a comprehensive suite of single-cell analysis technologies that simultaneously profile diverse regulatory processes—including DNA methylation, histone modification, and alternative RNA splicing—and integrate data related to chromatin states and transcript isoform expression. The research leverages particle-templated instant partitioning (PIP) barcoding technology to enhance reproducibility and efficiency in multi-omic applications, with the goal of improving transcript profiling and quantification through simultaneous short- and long-read sequencing methods. The work addresses a significant gap in identifying abnormal interaction patterns specific to disease-related cell subpopulations, with potential applications to autoimmune diseases, neurodegenerative conditions, and cancers. Work is performed in Philadelphia, Pennsylvania, with a period of performance extending through June 30, 2031. This is a Project Grant, an assistance type providing time-limited support for discrete research projects under peer review.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $506.6k | 9/2/26 |