Project Grant R35GM162442
- Federal Grant Award Summary The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, received a $471,625 Project Grant awarded August 1, 2025, through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The award, with a completion date of May 31, 2030, funds fundamental research investigating the mechanisms controlling epithelial tube development, orientation, and integrity. The research employs the sea star...
- Federal Grant Award Summary The Mount Desert Island Biological Laboratory received a $464,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with completion targeted for January 31, 2031. The award funds fundamental research exploring tissue-specific mechanisms and requirements for nucleolin (NCL) organization in living organisms, with a focus on understanding...
- Federal Project Grant Award Summary The Marine Biological Laboratory (MBL) received a $399,985 Project Grant from the National Science Foundation's Division of Environmental Biology (CFDA 47.074, Biological Sciences program) for the period September 1, 2025, through August 31, 2028. The award funds the Microbial Biodiversity Advanced Research Training Course, an intensive six-week training program that has served as a premier educational experience for early-career researchers in microbial...
- Federal Project Grant Award Summary The University of Massachusetts Boston received a $422,173 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025 through June 30, 2030. The award funds fundamental basic research investigating cellular signaling networks that control organism development and tissue patterning. The research employs the fruit fly Drosophila as a model...
- Federal Grant Award Summary The Marine Biological Laboratory (MBL) received a $1,250,907 Project Grant award from the National Science Foundation's Office of Integrative Activities (CFDA 47.083) effective February 1, 2026, through January 31, 2029. The award supports the acquisition and deployment of a JEOL JEM-120I Transmission Electron Microscope (TEM) equipped with 3D tomography capabilities at MBL's Central Microscopy Facility in Woods Hole, Massachusetts. This state-of-the-art imaging...
- Federal Project Grant Award Summary The Mount Desert Island Biological Laboratory (MDIBL) received a $432,543 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award funds the Emerging Leaders in Regenerative Biology and Development (REBILD) program, designed to address the critical workforce shortage in regenerative and developmental biology...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $441,375 Project Grant to the University of California, Berkeley, effective April 1, 2026 through March 31, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental research investigating the cellular and developmental mechanisms underlying animal responses to intracellular beneficial microbes. The research utilizes the sea anemone...
- Federal Project Grant Award Summary Award Details: The National Institute of General Medical Sciences (NIGMS) awarded $154,664 to Harvard Medical School on January 31, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The project is scheduled for completion by November 30, 2028. Research Scope and Deliverables: This project investigates the cellular and molecular mechanisms underlying kleptoplasty—the retention and integration of stolen chloroplasts within...
- Federal Project Grant Award Summary The Washington University received a Project Grant award of $427,625 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award supports fundamental research investigating the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research employs advanced...
- Federal Project Grant Summary The Mount Desert Island Biological Laboratory received a $422,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through January 31, 2031. This award funds research into the molecular mechanisms of limb and tail regeneration in axolotls, with the ultimate goal of enabling development of novel strategies for scarless tissue regeneration in...
The Marine Biological Laboratory (MBL) received a $471,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, through February 28, 2031. This award funds fundamental basic research investigating Wnt pathway activation mechanisms using sea star oocytes as a cellular model system. The research focuses on characterizing the composition, assembly, and function of Dishevelled (DVL) cytoplasmic assemblies and oocyte-derived microtubule projections (OMPs), which are hypothesized to facilitate long-distance Wnt signaling between cells. This investigation addresses critical gaps in understanding biochemical communication mechanisms essential to early developmental processes, including body axis establishment and gastrulation, while potentially informing understanding of Wnt pathway dysregulation in cancer development. The research leverages MBL's specialized capabilities as a premier non-profit research institution in Woods Hole, Massachusetts, providing advanced research infrastructure and technical expertise for complex developmental biology investigations. The project generates fundamental scientific knowledge regarding conserved cellular signaling pathways through controlled experimental work conducted in the institution's specialized laboratory facilities. Findings from this investigation are intended to advance the broader scientific understanding of biological processes underlying normal development and disease pathogenesis, consistent with NIGMS's mission to support basic biomedical research that increases understanding of fundamental biological mechanisms and provides foundational knowledge for future advances in disease diagnosis, treatment, and prevention.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.6k | 3/11/26 |