Project Grant R35GM161728
- The National Institutes of Health National Human Genome Research Institute awarded the University of Washington $444,794 on May 1, 2026, under the Human Genome Research program (CFDA 93.172) to conduct molecular characterization of nuclear body assembly and pathological misassembly. The award funds research into how three-dimensional nuclear architecture regulates genomic functions, specifically examining nuclear bodies—membraneless organelles including nucleoli, nuclear speckles, and Cajal...
- The National Institute of General Medical Sciences awarded the University of California, Davis $391,526 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for detecting and interpreting structural variants in complex genomic regions and their contribution to complex diseases including neurodevelopmental disorders and cancers. The research addresses gaps in current large-scale genomic studies by focusing on structural...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $363,191 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the role of non-canonical nucleic acid structures in genome regulation. The funded work investigates how non-canonical DNA structures—specifically R-loops (three-stranded RNA-DNA hybrid structures formed during transcription) and G-quadruplexes (four-stranded...
- The National Institutes of Health National Human Genome Research Institute awarded New York University $466,125 on May 18, 2026, under CFDA 93.172 (Human Genome Research) to support cross-species analysis of regulatory genomic function using synthetic regulatory genomics. The award funds development and application of the BIG-IN genome engineering technology to characterize regulatory DNA function across a phylogenetic tree. The recipient will analyze model genomic loci in mouse embryonic stem...
- The National Institute of General Medical Sciences awarded Sanford Burnham Prebys Medical Discovery Institute $2,903,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of nuclear pore complex formation. The project, titled "Molecular Basis of Nuclear Pore Formation," will define regulatory principles governing nuclear pore biogenesis in mammalian cells. The research addresses how alterations in...
- The National Institute of General Medical Sciences awarded Fred Hutchinson Cancer Center $613,838 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of dynamic cytoskeleton and membrane interactions critical for cell survival and repair. The research focuses on how cells rapidly repair injuries to the plasma membrane and nuclear envelope caused by physiological stress, trauma, infection, or disease. The principal investigator's...
- The National Institute of General Medical Sciences awarded Northwestern University $428,064 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct experimental and theoretical analysis of principles underlying molecular and genomic mechanobiology. The funded research examines chromosome structure and dynamics using cell- and molecule-scale mechanics combined with genetic, biochemical, single-molecule, and mathematical modeling approaches. The...
- The National Institute of General Medical Sciences awarded University of Massachusetts Boston $249,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the functional consequences of evolutionary innovation in histone H2A repertoires. The research uses evolutionary innovations in eukaryotic histone proteins to examine how histone repertoires have undergone lineage-specific changes and what selective advantages these changes confer....
- The National Institutes of Health National Human Genome Research Institute awarded the University of Connecticut $805,000 on September 20, 2025, under the Human Genome Research program (CFDA 93.172) to develop predictive methods for discovering and assessing non-B DNA structures using nanopore sequencing translocation times. The project addresses a scientific gap in reliably predicting non-canonical DNA structures, which are implicated in genetic disorders, carcinogenesis, and regulation of...
- The National Institute of General Medical Sciences awarded Seattle Children's Research Institute $2.096 million on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an AI-driven platform for generating conditionally stable nanobodies for intracellular detection and protein manipulation applications. The project spans four years through April 30, 2030, and will deliver three core outputs. First, an expanded AI-based nanobody stability prediction...
The National Institute of General Medical Sciences awarded the Pacific Northwest Research Institute $1,231,446 in project grant funding on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the origin and functional impact of "hidden" structural variants in rare genetic diseases. The research examines DNA structural variants including inversions, complex genomic rearrangements, mobile element insertions, and balanced translocations that escape detection by routine genome sequencing. The work focuses on understanding how DNA repair mechanisms such as break-induced replication and microhomology-mediated break-induced replication contribute to the germline formation of these variants, particularly in genomic regions containing highly similar intrachromosomal repeats. The project aims to establish the molecular features and mechanisms of variant generation and their impact on disease expression, with emphasis on how these variants perturb dosage-sensitive genes. Performance runs through May 31, 2031, at the recipient's Seattle, Washington location. The funding supports basic research to advance understanding of biological processes underlying genomic disorders and lay the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/1/26 |